Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, M. Curie-Skłodowska 3, 20-031, Lublin, Poland; Department of Biophysics, Institute of Physics, Maria Curie-Skłodowska University, Pl. M. Curie-Skłodowskiej 1, 20-031, Lublin, Poland.
Department of Environmental Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Kraków, Poland.
Chem Phys Lipids. 2021 Mar;235:105059. doi: 10.1016/j.chemphyslip.2021.105059. Epub 2021 Feb 1.
Surfactants are commonly found in today's world as an essential component of cleaning detergents, cosmetics and drug delivery systems. They can penetrate into lipid membranes, thus changing their properties. The aim of this paper is to compare the effect of addition of small amounts of cationic (DTAB) and anionic surfactants (SDS) with the same alkyl chain length on the zeta potential of DPPC liposomes with their influence on the corresponding DPPC monolayers. It was found that the addition of ionic surfactants with an initial concentration in the solution equal to 2.3, 4.5 and 9.1 μM to the liposome suspension changes their electrokinetic potential significantly. These changes increase with the increasing surfactant concentration and are greater for the anionic surfactant. This indicates the incorporation of surfactants into the structure of liposomes. Based on the analysis of π-area isotherms of DPPC monolayers it was proved that the ionic surfactant molecules are irreversibly integrated into the DPPC monolayer.
表面活性剂在当今世界被广泛用作清洁洗涤剂、化妆品和药物输送系统的重要组成部分。它们可以穿透脂质膜，从而改变其性质。本文旨在比较添加少量阳离子（DTAB）和阴离子表面活性剂（SDS）与相同烷基链长对 DPPC 脂质体的 ζ 电位的影响及其对相应 DPPC 单层的影响。结果发现，向脂质体悬浮液中添加初始浓度等于 2.3、4.5 和 9.1 μM 的离子表面活性剂会显著改变其动电势。这些变化随表面活性剂浓度的增加而增加，对于阴离子表面活性剂则更大。这表明表面活性剂已掺入脂质体的结构中。基于 DPPC 单层的 π-面积等温线分析，证明了离子表面活性剂分子不可逆地整合到 DPPC 单层中。
