McConlogue C W, Malamud D, Vanderlick T K
Department of Chemical Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Biochim Biophys Acta. 1998 Jun 24;1372(1):124-34. doi: 10.1016/s0005-2736(98)00052-2.
We studied the effects of four soluble surfactants on DPPC monolayers to elucidate the action of these membrane perturbants. The presence of nonionic N-9 and amphoteric C31G strongly affected the pure DPPC isotherm, while anionic SDS and cationic DTAB had little effect. The impact of surfactant on DPPC domain shape in the liquid condensed-liquid expanded coexistence region showed the opposite result. Neutral surfactants had minimal effect on the shape of DPPC domains; charged surfactants, on the other hand, induced a new shape transition at high surface pressures previously unreported for DPPC domains. All of these results are discussed with particular attention given to electrostatic effects at the interface.
我们研究了四种可溶性表面活性剂对二棕榈酰磷脂酰胆碱（DPPC）单层膜的影响，以阐明这些膜扰动剂的作用。非离子型N-9和两性离子型C31G的存在强烈影响了纯DPPC等温线，而阴离子型十二烷基硫酸钠（SDS）和阳离子型十二烷基三甲基溴化铵（DTAB）的影响较小。表面活性剂对DPPC在液-液共存区域的畴形状的影响显示出相反的结果。中性表面活性剂对DPPC畴形状的影响最小；另一方面，带电表面活性剂在高表面压力下诱导了一种新的形状转变，这是DPPC畴以前未报道过的。所有这些结果都进行了讨论，特别关注了界面处的静电效应。
