Moon Summer D, Spencer James M
Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA.
J Drugs Dermatol. 2013 Jan;12(1):107-8.
A 93-year-old woman presented with biopsy-proven invasive melanoma of 2.75 mm depth, arising from a melanoma in situ. Standard treatment of this depth would be an extensive and mutilating excision, which presented a therapeutic dilemma. Imiquimod has the ability to clear melanoma in situ, but its effect on invasive melanoma is unknown. After a thorough discussion with the patient, we decided to attempt to treat the melanoma in situ with topical imiquimod and then excise the smaller invasive component. Following 5 weeks of topical imiquimod therapy, the area where the nodular melanoma had previously been was excised. Histological examination of the excisional specimen revealed no residual melanoma detected. In this case, it appears that 5 weeks of topical imiquimod therapy completely cleared an invasive melanoma of 2.75 mm depth, as well as clearing the component of melanoma in situ. The patient was followed for 14 months with no evidence of recurrence.
一名93岁女性，经活检证实患有深度为2.75毫米的浸润性黑色素瘤，起源于原位黑色素瘤。这种深度的标准治疗方法是进行广泛且致残性的切除，这带来了治疗难题。咪喹莫特能够清除原位黑色素瘤，但其对浸润性黑色素瘤的效果尚不清楚。在与患者进行充分讨论后，我们决定先用咪喹莫特局部治疗原位黑色素瘤，然后切除较小的浸润成分。经过5周的咪喹莫特局部治疗后，切除了先前结节性黑色素瘤所在的区域。切除标本的组织学检查未发现残留黑色素瘤。在本病例中，5周的咪喹莫特局部治疗似乎完全清除了深度为2.75毫米的浸润性黑色素瘤以及原位黑色素瘤成分。对患者进行了14个月的随访，无复发迹象。
