Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.
Adv Exp Med Biol. 2013;774:225-50. doi: 10.1007/978-94-007-5590-1_12.
Over the last decade thousands of microRNAs (miRNAs) have been discovered in all kinds of taxa. The ever growing number of identified miRNA genes required ordered cataloging and annotation. This has led to the development of miRNA web resources.MiRNA web resources can be referred to either as web accessible databases (repositories) or web applications that provide a defined computational task upon user request. Today, more than three dozen web accessible resources exist that gather, organize and annotate all kinds of miRNA related data. According to the type of data or data processing method, these miRNA web resources can be classified as miRNA sequence and annotation databases, resources and tools for predicted as well as experimentally validated targets, databases of miRNA regulation and expression, functional annotation and mapping databases and a number of other tools and resources that are species-specific or focus on particular phenotypes.This chapter provides an overview of the different types of miRNA web resources and their purpose and gives some examples for each category. Furthermore, some valuable miRNA web applications will be introduced. Finally, strategies for miRNA data retrieval and associated risks and pitfalls will be discussed.
在过去的十年中，在各种分类单元中发现了成千上万的 microRNAs (miRNAs)。越来越多的已鉴定 miRNA 基因需要进行有序编目和注释。这导致了 miRNA 网络资源的发展。miRNA 网络资源可以指可通过网络访问的数据库（存储库），也可以指根据用户请求提供定义计算任务的网络应用程序。如今，存在三十多个可通过网络访问的资源，这些资源汇集、组织和注释各种 miRNA 相关数据。根据数据类型或数据处理方法，这些 miRNA 网络资源可以分为 miRNA 序列和注释数据库、预测和实验验证靶标相关的资源和工具、miRNA 调控和表达数据库、功能注释和映射数据库以及许多其他针对特定物种或特定表型的工具和资源。本章概述了不同类型的 miRNA 网络资源及其用途，并为每个类别提供了一些示例。此外，还将介绍一些有价值的 miRNA 网络应用程序。最后，将讨论 miRNA 数据检索的策略以及相关的风险和陷阱。
