McGregor I S, Menéndez J A, Atrens D M
Department of Psychology, University of Sydney, NSW, Australia.
Brain Res Bull. 1990 Mar;24(3):363-7. doi: 10.1016/0361-9230(90)90090-m.
The metabolic effects of 10, 39 and 156 pmol doses of neuropeptide Y (NPY) injected into the sulcal prefrontal cortex (SPC) were investigated in an open-circuit calorimeter. The 39 pmol dose produced a large and long lasting increase in respiratory quotient indicating both increased utilization of carbohydrate as an energy substrate and the synthesis of fat from carbohydrate. The 10 and 39 pmol doses produced an inhibition of energy expenditure that was still evident 24 hours following the 10, but not the 39 pmol, dose. These energy expenditure effects appeared to reflect an inhibition of thermogenesis as they were not systematically related to changes in locomotor activity. In separate tests, 39 pmol NPY reliably enhanced food intake. This combination of effects, namely increased carbohydrate utilization, fat synthesis and food intake with reduced energy expenditure, shows NPY to be a potent anabolic force. In addition, these results indicate both the functional significance of NPY at a cortical level and the important role of the SPC in the control of energy balance.
在开路热量计中研究了向沟回前额叶皮质（SPC）注射10、39和156皮摩尔剂量神经肽Y（NPY）的代谢效应。39皮摩尔剂量使呼吸商大幅且持久升高，表明碳水化合物作为能量底物的利用率增加以及由碳水化合物合成脂肪。10和39皮摩尔剂量均产生了能量消耗抑制，10皮摩尔剂量后24小时这种抑制仍很明显，但39皮摩尔剂量后则不明显。这些能量消耗效应似乎反映了产热的抑制，因为它们与运动活动的变化没有系统性关联。在单独的试验中，39皮摩尔NPY可靠地增加了食物摄入量。这种效应的组合，即碳水化合物利用率增加、脂肪合成和食物摄入量增加以及能量消耗减少，表明NPY是一种强大的合成代谢力量。此外，这些结果表明NPY在皮质水平的功能意义以及SPC在能量平衡控制中的重要作用。
