Smiałowski A, Lewińska-Gastoł L, Smiałowska M
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Neuropeptides. 1992 Mar;21(3):153-6. doi: 10.1016/0143-4179(92)90038-x.
The aim of this study was to investigate the influence of intracortical administration of neuropeptide-Y on the behaviour of rats. One week before the behavioural test the frontal cortex of rats was chronically implanted with intracerebral cannulae. Neuropeptide-Y (or saline in the control group) was injected in a volume of 1 microliter. After treatment the behaviour of the rats was tested in an open field apparatus and a light-beam actometer. The number of line crossings, episodes of rearing, sniffing, washing and head poking were counted. The results indicate that administration of neuropeptide-Y to the frontal cortex of rats slightly increased exploratory and locomotor activity.
本研究的目的是探讨向大鼠皮层内注射神经肽Y对其行为的影响。在行为测试前一周，将脑内套管长期植入大鼠额叶皮层。注射1微升神经肽Y（对照组注射生理盐水）。处理后，在旷场装置和光束活动计中测试大鼠的行为。统计大鼠穿越线条的次数、直立次数、嗅探次数、梳理次数和探头次数。结果表明，向大鼠额叶皮层注射神经肽Y会轻微增加探索性和运动活性。
