Rab27 GTPases 及其效应物对囊泡运输和白细胞功能的调节。
Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors.
机构信息
1.The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.
出版信息
J Leukoc Biol. 2013 Oct;94(4):613-22. doi: 10.1189/jlb.1112600. Epub 2013 Feb 1.
Abstract
The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell-specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. This review focuses on the latest discoveries on the function of Rab27 GTPases and their effectors Munc13-4 and Slp1 in neutrophil function comparatively to their functions in other leukocytes.
摘要
Rab27 家族 GTPases 调节造血细胞（包括中性粒细胞、CTL、NK 细胞和肥大细胞）胞吐作用的效率和特异性。然而，Rab27 GTPases 调节的机制是细胞特异性的，因为它们取决于通过 GTPases 募集的特定效应分子的差异表达和功能。此外，Rab27 GTPases 参与分泌过程调节的多个步骤，包括通过与多个效应分子的连续相互作用进行初始、连接、对接和融合。最后，最近的报告表明，Rab27 GTPases 及其效应分子 Munc13-4 和 Slp1 除了调节胞吐作用之外，还调节其他囊泡运输机制，包括内吞作用和吞噬作用。本综述重点介绍了 Rab27 GTPases 及其效应分子 Munc13-4 和 Slp1 在中性粒细胞功能方面的最新发现，并与它们在其他白细胞中的功能进行了比较。
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