Stroup R, Sheibani K, Misset J L, Szekely A M, Tremblay G, Rappaport H
James Irvine Center for the Study of Leukemia and Lymphoma, City of Hope National Medical Center, Duarte, California 91010.
Cancer. 1990 Jun 1;65(11):2559-63. doi: 10.1002/1097-0142(19900601)65:11<2559::aid-cncr2820651127>3.0.co;2-e.
Lymphoblastic lymphomas (LBL) are a morphologically homogeneous group of non-Hodgkin's lymphomas which are indistinguishable in tissue sections from acute lymphoblastic leukemia (ALL). Although initial immunologic studies of LBL suggested that these lymphomas are of the T-cell phenotype, investigations have recently described patients with LBL having pre-B-cell, "common" ALL, and natural killer cell phenotypes. The authors recently reported detailed immunophenotypic characteristics in 36 cases of LBL, including a single case of LBL with a surface immunoglobulin-positive B-cell phenotype. Three additional patients with LBL whose cells expressed monoclonal serum immunoglobulins are presented here. In addition, the neoplastic lymphocytes expressed several B-cell-associated antigens. The tumor cells in the single case tested were TdT-negative. Despite the unusual immunologic phenotype, the morphologic features in all three cases were characteristic of LBL. In addition to the previously reported single case, to the authors' knowledge these are the only reported cases of a previously unrecognized variant of LBL: surface immunoglobulin-positive, B-cell LBL.
淋巴母细胞淋巴瘤（LBL）是一组形态学上同质化的非霍奇金淋巴瘤，在组织切片中与急性淋巴细胞白血病（ALL）难以区分。尽管对LBL的初步免疫学研究表明这些淋巴瘤具有T细胞表型，但最近的研究描述了具有前B细胞、“普通”ALL和自然杀伤细胞表型的LBL患者。作者最近报告了36例LBL的详细免疫表型特征，包括1例具有表面免疫球蛋白阳性B细胞表型的LBL。本文介绍了另外3例LBL患者，其细胞表达单克隆血清免疫球蛋白。此外，肿瘤淋巴细胞表达了几种B细胞相关抗原。所检测的单个病例中的肿瘤细胞TdT阴性。尽管免疫表型不寻常，但所有3例的形态学特征均为LBL的特征。除了先前报告的单个病例外，据作者所知，这些是先前未被认识的LBL变体：表面免疫球蛋白阳性B细胞LBL的仅有的报告病例。
