Mousavi Seyyedeh Mahbubeh, Imani Sohrab, Haghighi Saeid, Mousavi Seyyedeh Elaheh, Karimi Akbar
Department of Entomology, Islamic Azad University, Tehran Science and Research Branch, Iran.
J Arthropod Borne Dis. 2012 Dec;6(2):136-43. Epub 2012 Dec 31.
Diabetes is an important disease. This disease is a metabolic disorder characterized by hyperglycemia resulting from perturbation in insulin secretion, insulin action or both. Honey bee venom contains a wide range of polypeptide agents. The principle components of bee venom are mellitin and phospholipase A(2). These components increase insulin secretion from the β-cells of pancreas. This study was conducted to show the hypoglycemic effect of honey bee venom on alloxan induced diabetic male rats.
Eighteen adult male rats weighting 200±20 g were placed into 3 randomly groups: control, alloxan monohydrate-induced diabetic rat and treated group that received honey bee venom daily before their nutrition for four months. Forty eight hours after the last injection, blood was collected from their heart, serum was dissented and blood glucose, insulin, triglyceride and total cholesterol were determined.
Glucose serum, triglyceride and total cholesterol level in treated group in comparison with diabetic group was significantly decreased (P< 0.01). On the other hand, using bee venom causes increase in insulin serum in comparison with diabetic group (P< 0.05).
Honeybee venom (apitoxin) can be used as therapeutic option to lower blood glucose and lipids in diabetic rats.
糖尿病是一种重要的疾病。这种疾病是一种代谢紊乱，其特征是由于胰岛素分泌、胰岛素作用或两者的扰动导致血糖升高。蜂毒含有多种多肽成分。蜂毒的主要成分是蜂毒肽和磷脂酶A2。这些成分可增加胰腺β细胞的胰岛素分泌。本研究旨在表明蜂毒对四氧嘧啶诱导的糖尿病雄性大鼠的降血糖作用。
将18只体重200±20 g的成年雄性大鼠随机分为3组：对照组、一水合四氧嘧啶诱导的糖尿病大鼠组和治疗组，治疗组在喂食前每日接受蜂毒注射，持续4个月。最后一次注射48小时后，从它们的心脏采集血液，分离血清并测定血糖、胰岛素、甘油三酯和总胆固醇。
与糖尿病组相比，治疗组的血糖、甘油三酯和总胆固醇水平显著降低（P<0.01）。另一方面，与糖尿病组相比，使用蜂毒可使血清胰岛素增加（P<0.05）。
蜂毒可作为降低糖尿病大鼠血糖和血脂的治疗选择。
