一种用于分析手性羟胺对映体纯度的 NMR 分析的简单方案。
A simple protocol for NMR analysis of the enantiomeric purity of chiral hydroxylamines.
机构信息
Department of Chemistry, University of Bath, Claverton Down, Bath, BA27AY, UK.
出版信息
Org Lett. 2013 Feb 15;15(4):860-3. doi: 10.1021/ol303566k. Epub 2013 Feb 4.
PMID:23379733
Abstract
A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral hydroxylamines by (1)H NMR spectroscopic analysis is described, involving their treatment with 2-formylphenylboronic acid and enantiopure BINOL to afford a mixture of diastereomeric nitrono-boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent hydroxylamine.
摘要
描述了一种实用简单的三组分手性衍生化方案，通过（1）H NMR 光谱分析来测定手性羟胺的对映体纯度，涉及用 2-醛基苯硼酸和手性纯 BINOL 处理它们，得到非对映异构体硝基硼酸酯的混合物，其比例准确反映了母体羟胺的对映体纯度。
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