参与发育中鸡胚肝脏腺嘌呤核苷酸代谢的酶。
Enzymes involved in adenine nucleotide metabolism of developing chick embryo liver.
作者信息
Wegelin I, Pane G, Manzoli F A
机构信息
Institute of Histology and General Embryology, University of Bologna, Italy.
出版信息
Comp Biochem Physiol B. 1978;61(2):327-9. doi: 10.1016/0305-0491(78)90183-9.
PMID:233801
Abstract
- This paper describes the changes in the activity of adenylate deaminase, adenylate and inosinate phosphatase, and adenosine deaminase in the developing chick embryo liver. 2. The adenylate and inosinate phosphatase and adenosine deaminase activity appears considerably higher in chick embryo liver with respect to other chick embryo tissues previously examined. 3. During development the control exerted by ATP on AMP breakdown undergoes variations. Consequently, in the first period of incubation AMP is degraded by the direct pathway (AMP-IMP) and in the last period of incubation by the indirect pathway (AMP-adenosine). In the intermediate period (from the 12th to the 15th day of incubation) both pathways may be followed. 4. The ability to synthesize purine nucleotides through "salvage pathway" seems to be acquired by embryonic liver at least at the 15th day.
摘要
- 本文描述了发育中的鸡胚肝脏中腺苷酸脱氨酶、腺苷酸和次黄苷酸磷酸酶以及腺苷脱氨酶活性的变化。2. 相对于先前检测的其他鸡胚组织，鸡胚肝脏中的腺苷酸和次黄苷酸磷酸酶以及腺苷脱氨酶活性明显更高。3. 在发育过程中，ATP对AMP分解的控制发生变化。因此，在孵化的第一阶段，AMP通过直接途径（AMP-IMP）降解，而在孵化的最后阶段通过间接途径（AMP-腺苷）降解。在中间阶段（孵化的第12天至第15天），两条途径都可能被采用。4. 胚胎肝脏至少在第15天似乎获得了通过“补救途径”合成嘌呤核苷酸的能力。
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引用本文的文献
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Developmental changes of chicken liver AMP deaminase.鸡肝脏AMP脱氨酶的发育变化
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