Litovchenko I N, Savitskiĭ I V
Biokhimiia. 1984 Aug;49(8):1248-52.
The activities of adenylate kinase, AMP-deaminase and 5'-nucleotidase in various tissues of the rat were studied. The activity of the forward adenylate kinase reaction (ATP + AMP----2 ADP) against the back one (2 ADP----ATP + AMP) was predominant. The liver was shown to contain two, while the blood serum--three adenylate kinase isoenzymes. In the skeletal muscles, the catabolism of adenylic acid involving AMP-deaminase and 5'-nucleotidase predominantly occurred via deamination, in the liver--via dephosphorylation, while in the leucocytes, erythrocytes and blood serum the activity of these processes was essentially the same. In vitro, ATP enhanced the activity of AMP-deaminase in the liver, leucocytes and erythrocytes and decreased it in the blood serum. Under effects of ATP, the activity of 5'-nucleotidase in the leucocytes and blood serum was markedly elevated, that in the liver and erythrocytes was unaffected.
对大鼠各种组织中腺苷酸激酶、AMP脱氨酶和5'-核苷酸酶的活性进行了研究。腺苷酸激酶正向反应（ATP + AMP→2 ADP）的活性相对于逆向反应（2 ADP→ATP + AMP）占主导地位。结果表明，肝脏含有两种腺苷酸激酶同工酶，而血清含有三种。在骨骼肌中，涉及AMP脱氨酶和5'-核苷酸酶的腺苷酸分解代谢主要通过脱氨进行，在肝脏中则通过去磷酸化进行，而在白细胞、红细胞和血清中，这些过程的活性基本相同。在体外，ATP增强了肝脏、白细胞和红细胞中AMP脱氨酶的活性，而降低了血清中的活性。在ATP的作用下，白细胞和血清中5'-核苷酸酶的活性显著升高，而肝脏和红细胞中的活性不受影响。
