Matsunaga T, Törmänen V
Unit for Applied Cell and Molecular Biology, University of Umeå, Sweden.
Dev Comp Immunol. 1990 Winter;14(1):1-8. doi: 10.1016/0145-305x(90)90002-v.
Structural homology present between antibody genes and T-cell antigen receptor (TCR) genes include not only V genes but also D and J segments. This may indicate that the gene duplication occurred involving a large chromosomal region containing all these genes and segments. It is conceivable, however, that the TCR gene complex is the ancestor, as effective selective forces to diversity V gene sequences are provided by MHC polymorphism only for TCR V genes. Consequently, we argue that the antibody repertoire may have emerged rather abruptly in evolution.
抗体基因与T细胞抗原受体（TCR）基因之间存在的结构同源性不仅包括V基因，还包括D和J片段。这可能表明基因复制发生在涉及包含所有这些基因和片段的大染色体区域。然而，可以想象，TCR基因复合体是祖先，因为只有TCR V基因的MHC多态性为V基因序列的多样性提供了有效的选择力。因此，我们认为抗体库可能在进化过程中相当突然地出现。
