Ota T, Sitnikova T, Nei M
Center for Human Genetics, Boston University School of Medicine, MA 02118, USA.
Curr Top Microbiol Immunol. 2000;248:221-45. doi: 10.1007/978-3-642-59674-2_10.
Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution. The change in somatic diversification system coupled with the change in lymphocyte development has imposed a significant impact on the evolution of Ig genes. In order to understand the evolution of immunological genes it is important to view it in the context of the evolution of the entire immune system itself.
免疫球蛋白V基因片段的进化通常具有以下特点：（a）通过“出生与死亡过程”进行进化，以及（b）多样化选择。然而，由于体液免疫系统在脊椎动物进化过程中自身发生了变化，V基因片段的详细进化模式在不同物种间存在差异。体细胞多样化系统的变化以及淋巴细胞发育的变化对免疫球蛋白基因的进化产生了重大影响。为了理解免疫基因的进化，在整个免疫系统自身进化的背景下看待它很重要。
