Department of Public Health, Weill Cornell Medical College, New York, NY, USA.
Am J Hypertens. 2013 Feb;26(2):174-9. doi: 10.1093/ajh/hps029. Epub 2012 Dec 28.
Highly publicized recommendations favor the use of diuretics as a first-line or add-on agent in the management of hypertension, particularly among black patients and patients with resistant hypertension. Failure to follow such guidelines might contribute to high rates of uncontrolled hypertension. This study assessed diuretic prescribing patterns in a sample of black patients with uncontrolled hypertension who were identified from a population of home care recipients.
The study was conducted in an urban home health organization. Participants were black, aged 21 to 80 years, and had a diagnosis of hypertension. Participants with uncontrolled hypertension were identified, and in-home interviewers collected information on prescribed antihypertensive medications.
Of 658 participants, 5.5% were not prescribed any antihypertensives, and only 46% were prescribed a diuretic. Participants who were not taking a diuretic were taking fewer antihypertensive medications (1.7 vs. 2.9; P < 0.0001), had a higher mean diastolic blood pressure (89.2 vs. 85.5; P = 0.0005), and were more likely to have a systolic blood pressure ≥160mm Hg (57.6% vs. 49.0%; P = 0.04). The adjusted mean systolic and diastolic blood pressures were 5 and 4mm Hg lower, respectively, in patients who were taking a diuretic.
In this sample of black patients with uncontrolled hypertension, despite wide publicizing of the recommendations for use of diuretics, a majority are still not receiving a diuretic. This important issue merits continued attention.
利尿剂作为高血压管理的一线或附加药物,尤其是在黑人患者和耐药性高血压患者中,已被广泛宣传推荐。不遵循这些指南可能导致高血压控制不佳的发生率居高不下。本研究评估了从家庭护理接受者人群中确定的未控制高血压黑人患者样本中利尿剂的处方模式。
本研究在一个城市家庭健康组织中进行。参与者为黑人,年龄在 21 至 80 岁之间,诊断为高血压。确定患有未控制高血压的参与者,家访人员收集了处方抗高血压药物的信息。
在 658 名参与者中,5.5%未开任何降压药,仅 46%开了利尿剂。未服用利尿剂的参与者服用的降压药物较少(1.7 种与 2.9 种;P < 0.0001),舒张压平均值较高(89.2 与 85.5mmHg;P = 0.0005),收缩压≥160mmHg 的可能性更高(57.6%与 49.0%;P = 0.04)。服用利尿剂的患者的平均收缩压和舒张压分别降低了 5mmHg 和 4mmHg。
在这个未控制高血压的黑人患者样本中,尽管利尿剂的使用建议被广泛宣传,但大多数患者仍未接受利尿剂治疗。这个重要问题值得持续关注。