de Juan E, Stefánsson E, Dickson J S
Duke University Eye Center, Durham, NC 27710.
Graefes Arch Clin Exp Ophthalmol. 1990;228(2):191-4. doi: 10.1007/BF00935732.
Since the 1940s, the major hypothesis regarding the stimulus for neovascularization occurring in diabetic retinopathy and other "ischemic" retinopathies has involved the release of a soluble angiogenic factor from the ischemic retina. We sought to test this by measuring the endothelial mitogenic activity that could be extracted from an ischemic retina caused by branch vein occlusion in the cat. We found that the extractable endothelial-cell mitogenic activity from normal retinal areas was similar to that in ischemic areas at 1, 2, and 7 days after the occlusion. In the area of occluded veins, the oxygen partial pressure was low (7 +/- 7 mm Hg) compared with the normal value (23 +/- 8 mm Hg). The data did not show any increase in soluble mitogenic factor release from the ischemic retina versus normal retinal areas under the conditions of this experiment.
自20世纪40年代以来，关于糖尿病性视网膜病变及其他“缺血性”视网膜病变中发生的新生血管形成刺激因素的主要假说是，缺血视网膜会释放一种可溶性血管生成因子。我们试图通过测量从猫的分支静脉阻塞所致缺血视网膜中提取的内皮细胞促有丝分裂活性来验证这一假说。我们发现，在阻塞后1天、2天和7天，正常视网膜区域可提取的内皮细胞促有丝分裂活性与缺血区域相似。在阻塞静脉区域，氧分压较低（7±7毫米汞柱），而正常值为（23±8毫米汞柱）。在本实验条件下，数据未显示缺血视网膜与正常视网膜区域相比，可溶性促有丝分裂因子释放有任何增加。
