Patz A
Am J Ophthalmol. 1982 Dec;94(6):715-43. doi: 10.1016/0002-9394(82)90297-5.
Retinal neovascularization is a serious complication of the retinopathy associated with diabetes, branch vein occlusion, sickle cell anemia, and retrolental fibroplasia. Retinal capillary nonperfusion, demonstrated on fluorescein angiography, precedes the development of neovascularization in each of these conditions. Our working hypothesis is that the nonperfused (ischemic or hypoxic) retina liberates a vasoproliferative or angiogenic substance. Although I have delineated the clinical and experimental observations relating to the hypothesis of an ischemic-mediated angiogenesis substance, other postulated mechanisms for the development of retinal neovascularization may be involved. Recent observations on the experimental model of retrolental fibroplasia have demonstrated the markedly abnormal persistence and apparent proliferation of the hyaloid vessels in mice following oxygen-induced retinal vascular closure.
视网膜新生血管形成是糖尿病性视网膜病变、视网膜分支静脉阻塞、镰状细胞贫血和晶状体后纤维增生症相关视网膜病变的严重并发症。荧光素血管造影显示的视网膜毛细血管无灌注，在上述每种情况下均先于新生血管形成。我们的工作假设是，无灌注（缺血或缺氧）的视网膜会释放一种血管增生或血管生成物质。尽管我已经阐述了与缺血介导的血管生成物质假说相关的临床和实验观察结果，但视网膜新生血管形成的其他假定机制也可能参与其中。最近对晶状体后纤维增生症实验模型的观察表明，在氧诱导的视网膜血管闭塞后，小鼠玻璃样血管明显异常持续存在并出现明显增生。
