Fontana L, De Sanctis G, Bottari V, Petti M C, Mandelli F
Dipartimento di Chirurgia, Università Tor Vergata, Roma, Italy.
Haematologica. 1990 Jan-Feb;75(1):46-9.
A short-term 51Cr-release assay was employed to investigate polymorphonuclear leukocyte (PMN) antibody-dependent (ADCC) and phytohemaglutinin-induced (PHA-ICC) cytotoxicity against chicken erythrocytes in 28 patients with myelodysplastic syndromes (MDS). MDS patients PMN-mediated ADCC and PHA-ICC were significantly reduced when compared to normal donors. When the patients were subdivided according to the revised FAB classification, a reduction in PHA-ICC from the RAEB group and a progressive impairment of ADCC from RA to RAEB-t patients was observed. These abnormalities may be ascribed to a reduced number of effector cells or to a metabolic impairment of their cytolytic capacity. These PMN functional deficiences may contribute to the increased susceptibility to infectious diseases, irrespective of the presence of granulocytopenia.
采用短期⁵¹Cr释放试验，研究了28例骨髓增生异常综合征（MDS）患者的多形核白细胞（PMN）抗体依赖性（ADCC）及植物血凝素诱导（PHA-ICC）的对鸡红细胞的细胞毒性。与正常供者相比，MDS患者PMN介导的ADCC和PHA-ICC显著降低。根据修订的FAB分类对患者进行细分时，观察到RAEB组PHA-ICC降低，且从RA到RAEB-t患者ADCC进行性受损。这些异常可能归因于效应细胞数量减少或其细胞溶解能力的代谢损害。无论是否存在粒细胞减少症，这些PMN功能缺陷可能导致对传染病易感性增加。
