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Ability of recombinant interferon gamma in vitro to restore the defective polymorphonuclear-cell- but not lymphocyte-mediated cytotoxic activities in patients with myelodysplastic syndromes.重组干扰素γ在体外恢复骨髓增生异常综合征患者缺陷性多形核细胞介导而非淋巴细胞介导的细胞毒活性的能力。
Cancer Immunol Immunother. 1992;34(6):414-8. doi: 10.1007/BF01741753.
2
Defective antibody-dependent and lectin-induced polymorphonuclear cytotoxicity in patients with myelodysplastic syndromes.骨髓增生异常综合征患者中抗体依赖性和凝集素诱导的多形核细胞毒性缺陷。
Haematologica. 1990 Jan-Feb;75(1):46-9.
3
Deficiency of lymphocyte lectin-dependent cytotoxicity in myelodysplastic syndromes.骨髓增生异常综合征中淋巴细胞凝集素依赖性细胞毒性的缺陷
Acta Haematol. 1989;82(1):1-6. doi: 10.1159/000205269.
4
Release of natural killer cytotoxic factor in patients with lymphoproliferative disease of granular lymphocytes.颗粒淋巴细胞淋巴增殖性疾病患者自然杀伤细胞毒性因子的释放
Leuk Res. 1989;13(4):315-22. doi: 10.1016/0145-2126(89)90068-4.
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CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets.CD16xCD33 双特异性杀伤细胞接合器 (BiKE) 激活 NK 细胞对抗原发性 MDS 和 MDSC CD33+靶标。
Blood. 2014 May 8;123(19):3016-26. doi: 10.1182/blood-2013-10-533398. Epub 2014 Mar 20.
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Effect of recombinant human interferons on NK and K cell activities of gnotobiotic miniature swine.重组人干扰素对无菌微型猪自然杀伤细胞和杀伤细胞活性的影响。
Prog Clin Biol Res. 1985;181:329-32.
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Augmentation of antibody-dependent cellular cytotoxicity of polymorphonuclear leukocytes by interferon-gamma: mechanism dependent on enhancement of Fc receptor expression and increased release of activated oxygens.γ干扰素增强多形核白细胞的抗体依赖性细胞毒性：其机制依赖于Fc受体表达的增强和活性氧释放的增加。
Chem Pharm Bull (Tokyo). 1987 Apr;35(4):1571-8. doi: 10.1248/cpb.35.1571.
8
Defective mitogen-induced cellular cytotoxicity in myelodysplastic syndromes. Recovery after alpha-interferon administration.骨髓增生异常综合征中有缺陷的丝裂原诱导的细胞毒性。α干扰素给药后的恢复情况。
Anticancer Res. 1991 Mar-Apr;11(2):685-9.
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Activation of cytotoxic T-cell receptor gammadelta T lymphocytes in response to specific stimulation in myelodysplastic syndromes.骨髓增生异常综合征中细胞毒性T细胞受体γδ T淋巴细胞在特定刺激下的激活。
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The role of interferon-gamma in the immunotherapy of neuroblastoma.γ干扰素在神经母细胞瘤免疫治疗中的作用。
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CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients.CD163+肿瘤相关巨噬细胞是一种预后生物标志物，且与肺癌患者恶性胸腔积液的治疗效果相关。
Oncotarget. 2015 Apr 30;6(12):10592-603. doi: 10.18632/oncotarget.3547.

本文引用的文献

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Immune interferon: a pleiotropic lymphokine with multiple effects.免疫干扰素：一种具有多种效应的多效性淋巴因子。
Immunol Today. 1985 Apr;6(4):131-6. doi: 10.1016/0167-5699(85)90080-5.
2
Impaired T-cell and NK-cell function in patients with preleukemia.白血病前期患者的T细胞和自然杀伤细胞功能受损。
Blut. 1982 Oct;45(4):243-8. doi: 10.1007/BF00320191.
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PHA-ICC, ADCC and NK in patients with ANLL in CR: human fibroblastic interferon fails to increase NK-active cell frequency.
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Surface markers of human natural killer cells as analyzed in a modified single cell cytotoxicity assay on poly-L-lysine coated cover slips.
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Blood neutrophil function in primary myelodysplastic syndromes.
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Lectin-dependent neutrophil-mediated cytotoxicity against chicken erythrocytes: a model of non-myeloperoxidase-mediated oxygen-dependent killing by human neutrophils.
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Human natural killer cells can inhibit clonogenic growth of fresh leukemic cells.人类自然杀伤细胞可抑制新鲜白血病细胞的克隆形成生长。
Blood. 1983 Mar;61(3):596-9.
8
Interferon enhances the antibody-dependent cellular cytotoxicity (ADCC) of human polymorphonuclear leukocytes.干扰素可增强人多形核白细胞的抗体依赖性细胞毒性（ADCC）。
J Immunol. 1981 Oct;127(4):1585-8.
9
Interferon activation of "pre-spontaneous killer" (pre-SK) cells and alteration in kinetics of lysis of both "pre-SK" and active SK cells.干扰素激活“前自发杀伤”（pre-SK）细胞，并改变“前SK”细胞和活性SK细胞的裂解动力学。
J Immunol. 1980 May;124(5):2157-61.
10
Immunoregulatory abnormalities in myelodysplastic disorders.骨髓增生异常综合征中的免疫调节异常。
Am J Hematol. 1986 May;22(1):17-26. doi: 10.1002/ajh.2830220104.

重组干扰素γ在体外恢复骨髓增生异常综合征患者缺陷性多形核细胞介导而非淋巴细胞介导的细胞毒活性的能力。

Ability of recombinant interferon gamma in vitro to restore the defective polymorphonuclear-cell- but not lymphocyte-mediated cytotoxic activities in patients with myelodysplastic syndromes.

作者信息

De Sanctis G, Bottari V, Frezzolini A, Ficcardi M, De Rossi G, Petti M C, Mandelli F, Fontana L

机构信息

Dipartimento di Chirurgia II Università di Roma, Italia.

出版信息

Cancer Immunol Immunother. 1992;34(6):414-8. doi: 10.1007/BF01741753.

DOI:10.1007/BF01741753
PMID:1563019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038437/
Abstract

In this study we analysed the in vitro effect of recombinant interferon gamma on cytotoxic activities mediated by both lymphoid and polymorphonuclear cells from 16 patients with myelodysplastic syndromes. Our results indicate the inability of interferon to restore the defective natural killer activity, natural killer cells and lectin-induced cytotoxicity. On the contrary we detected a boosting effect on the depressed polymorphonuclear cell cytotoxic activities. In our view, the ability of interferon to potentiate polymorphonuclear cell lytic efficiency could support an alternative defensive pathway against either neoplastic or infectious agents.

摘要

在本研究中，我们分析了重组干扰素γ对16例骨髓增生异常综合征患者的淋巴细胞和多形核细胞介导的细胞毒性活性的体外作用。我们的结果表明，干扰素无法恢复缺陷的自然杀伤活性、自然杀伤细胞和凝集素诱导的细胞毒性。相反，我们检测到对降低的多形核细胞细胞毒性活性有增强作用。我们认为，干扰素增强多形核细胞裂解效率的能力可能支持针对肿瘤或感染因子的另一种防御途径。