Chen Xiulai, Li Shubo, Liu Liming
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Wei Sheng Wu Xue Bao. 2012 Nov 4;52(11):1311-7.
A multi-vitamin auxotrophic yeast of Torulopsis glabrata was the most competitive strain for industrial production of pyruvate. Given its genomic characterizations and physiological functions, it was an efficient way to redirect carbon flux to the target metabolites through manipulating nutritional and environmental conditions, intracellular cofactor form and level. In this review, we summarized the progress on the elucidation and manipulation of physiological function of T. glabrata. Furthermore, we also evaluated the potential of T. glabrata as cell factory for production of fine chemicals.
光滑球拟酵母的一种多种维生素营养缺陷型酵母是丙酮酸工业生产中最具竞争力的菌株。鉴于其基因组特征和生理功能，通过控制营养和环境条件、细胞内辅因子形式和水平将碳通量重定向至目标代谢物是一种有效的方法。在本综述中，我们总结了光滑球拟酵母生理功能解析和调控方面的进展。此外，我们还评估了光滑球拟酵母作为精细化学品生产细胞工厂的潜力。
