Gołab-Janowska Monika, Nowacki Przemysław
Katedra i Klinika Neurologii Pomorskiego Uniwersytetu Medycznego w Szczecinie, ul. Unii Lubelskiej 1, 71-252 Szczecin.
Ann Acad Med Stetin. 2011;57(3):5-11.
Limbic encephalitis (LE) was described for the first time in 1960 as a clinico-pathologic syndrome in adults. Noninfectious LE usually demonstrates features of the paraneoplastic syndrome and is attributed in most cases to small cell lung cancer. Infectious LE is overwhelmingly caused by the herpes simplex virus. Non-paraneoplastic variants of LE (NPLE) are associated with autoimmune diseases and demonstrate antibodies against cell membrane antigens. However, there are cases of NPLE diagnosed on the basis of the clinical picture, MRI findings, absence of tumor, and long-term follow-up results, which do not reveal the aforementioned antibodies, are not preceded by symptoms of acute febrile infection, and present with temporal lobe epilepsy as the prominent symptom. NPLE is a potentially reversible variant of LE. Until now, no diagnostic consensus as regards LE subtypes has been achieved. The authors present current diagnostic criteria and propose recommendations concerning treatment.
边缘叶脑炎（LE）于1960年首次被描述为成人的一种临床病理综合征。非感染性LE通常表现为副肿瘤综合征的特征，在大多数情况下归因于小细胞肺癌。感染性LE绝大多数由单纯疱疹病毒引起。LE的非副肿瘤变体（NPLE）与自身免疫性疾病相关，并显示出针对细胞膜抗原的抗体。然而，有一些NPLE病例是根据临床表现、MRI结果、无肿瘤以及长期随访结果诊断出来的，这些病例未发现上述抗体，没有急性发热感染症状，且以颞叶癫痫为突出症状。NPLE是LE的一种潜在可逆变体。到目前为止，关于LE亚型尚未达成诊断共识。作者介绍了当前的诊断标准并提出了治疗建议。
