Department of Pediatrics, Washington University and St. Louis Children's Hospital, St. Louis, Missouri, USA.
Curr Opin Allergy Clin Immunol. 2013 Apr;13(2):211-6. doi: 10.1097/ACI.0b013e32835eb6ef.
PROPOSE OF REVIEW: Cumulative evidence suggest that early life bronchiolitis is a major risk factor for subsequent wheezing episodes and asthma. The purpose of this review is to present the recent findings and current perspectives regarding the interplay between bronchiolitis and long-term respiratory outcomes.
Recent studies have supported the long-recognized link between early life severe respiratory syncytial virus bronchiolitis and the physician diagnosis of asthma by school age, and this association appears to continue into early adulthood. Evidence is accumulating regarding the role of early life infection with human rhinovirus as an important antecedent for future asthma. Whether viral bronchiolitis is causal or an early manifestation of future asthma remains uncertain. Vitamin D status has emerged as a potential modifying factor for viral-induced wheeze and could potentially influence the development of asthma.
Viral bronchiolitis early in life is a major and potential long-term risk factor for subsequent wheezing and asthma. Whether the association between bronchiolitis and subsequent asthma is due to causality or a reflection of predisposition may be dependent on host factors and virus-specific effects.
综述目的在于呈现有关细支气管炎与长期呼吸道结局之间相互作用的最新发现和当前观点。
婴儿期病毒性细支气管炎是发生后续喘息和哮喘的一个主要且潜在的长期危险因素。细支气管炎与后续哮喘之间的关联是由因果关系还是反映易感性所致，可能取决于宿主因素和病毒特异性效应。
综述目的在于呈现有关细支气管炎与长期呼吸道结局之间相互作用的最新发现和当前观点。
最近的研究支持了这样一种长期公认的关联，即婴儿期严重呼吸道合胞病毒细支气管炎与学龄期医生诊断的哮喘之间存在关联，而且这种关联似乎会持续到成年早期。越来越多的证据表明，人类鼻病毒感染在婴儿期作为未来哮喘的一个重要前驱因素发挥作用。病毒性细支气管炎是否是因果关系或未来哮喘的早期表现仍不确定。维生素 D 状态已成为病毒诱发喘息的一个潜在调节因素，可能会影响哮喘的发生。
