Joyce M A, Lorenz J W
Sterling Drug Inc., Rensselaer, New York.
J Parenter Sci Technol. 1990 Mar-Apr;44(2):54-7.
The force applied to the closure of a parenteral container is a critical parameter in assuring the integrity of a seal. Measurement of the force can be accomplished either off line, through residual force measurements, or on line, through instrumentation of the sealing station. The instrumentation of the sealing station provides a dynamic profile of the sealing event for development of the optimal sealing parameters. A computer interface for this application has been developed using a standard IBM-AT and commercially available data acquisition hardware and software. The resultant data can be set up in Lotus 1-2-3, or any other analysis package capable of importing ASCII files, for graphic display, and/or additional analysis. The system thus provides a means to acquire quantitative data on the sealing event for development of optimal sealing parameters.
施加于非肠道容器封闭的力是确保密封完整性的关键参数。该力的测量既可以离线进行，通过残余力测量；也可以在线进行，通过密封工位的仪器测量。密封工位的仪器为优化密封参数的制定提供了密封过程的动态曲线。针对此应用，已使用标准IBM-AT计算机以及商用数据采集硬件和软件开发了一个计算机接口。所得数据可以在Lotus 1-2-3或任何其他能够导入ASCII文件的分析软件包中进行设置，以进行图形显示和/或进一步分析。因此，该系统提供了一种获取密封过程定量数据以制定最佳密封参数的方法。
