Reykjavik Primary Health Care, Glaesibaer, 104 Reykjavik, Iceland.
Foot Ankle Int. 2013 Jun;34(6):841-5. doi: 10.1177/1071100713475352. Epub 2013 Feb 5.
Fibromatous nodules in the sole of the foot are often called Ledderhose disease. It is a benign nodular formation in the plantar aponeurosis, typically at the distal medial border. A lump forms and it can be a few centimeters in diameter. It is frequently seen as an isolated disease, but a relationship to Dupuytren's has been noted in some patients.
The study was a part of a large cohort study, the Reykjavík study. Men with Dupuytren's disease (n = 122) were invited to follow-up 18 years after the initial observation. An equal number of controls, matched for age and smoking habits, were also invited. A total of 92 Dupuytren's patients and 101 control subjects attended for follow-up and were examined for plantar nodules. Statistical evaluation was carried out using chi-square test and presented as odds ratio (OR) and 95% confidence interval (95% CI).
Ledderhose disease was identified in 14 of the 92 (15.2%) men with Dupuytren's disease, while it was only in 4 of the 101 (3.9%) matched controls (OR = 4.35, 95% CI, 1.3-16.7, P < 0.01). Men operated for Dupuytren's disease or with finger contractures were more likely to have plantar nodules than those with only nodules or strings in the palms (OR = 6.1, 95% CI, 1.8-27.1, P < 0.001). The plantar involvement was related to family history of Dupuytren's disease (OR = 3.1, 95% CI, 1.1-8.5, P = 0.02).
Men with manifestations of finger contractures or who need surgery for Dupuytren's disease are more likely to also develop plantar fibromas.
Level III, retrospective comparative series.
足底的纤维瘤结节通常被称为莱德豪泽病。它是一种足底腱膜的良性结节形成，通常位于远端内侧边界。形成一个肿块，直径可达几厘米。它通常作为一种孤立的疾病出现，但在一些患者中已经注意到与掌腱膜挛缩症的关系。
该研究是雷克雅未克研究的一部分，这是一项大型队列研究。患有掌腱膜挛缩症的男性（n=122）被邀请在首次观察后 18 年进行随访。同时还邀请了年龄和吸烟习惯相匹配的 122 名对照组男性。共有 92 名掌腱膜挛缩症患者和 101 名对照组男性参加了随访，并接受了足底结节检查。使用卡方检验进行统计评估，并以比值比（OR）和 95%置信区间（95%CI）表示。
在 92 名患有掌腱膜挛缩症的男性中，有 14 名（15.2%）患有莱德豪泽病，而在 101 名对照组男性中，只有 4 名（3.9%）患有该疾病（OR=4.35，95%CI，1.3-16.7，P<0.01）。接受掌腱膜挛缩症手术或手指挛缩的男性比仅有手掌结节或索带的男性更容易出现足底结节（OR=6.1，95%CI，1.8-27.1，P<0.001）。足底受累与掌腱膜挛缩症家族史有关（OR=3.1，95%CI，1.1-8.5，P=0.02）。
有手指挛缩表现或需要掌腱膜挛缩症手术的男性更有可能出现足底纤维瘤。
III 级，回顾性比较系列。
