犬瘟热病毒引起的松鼠猴脑炎。
Encephalitis induced by a canine distemper virus in squirrel monkeys.
作者信息
Nagata T, Ochikubo F, Yoshikawa Y, Yamanouchi K
机构信息
Laboratory Animal Research Center, University of Tokyo, Japan.
出版信息
J Med Primatol. 1990;19(2):137-49.
Intracerebral inoculation with canine distemper virus (CDV) caused acute neurological signs of viral encephalitis in squirrel monkeys. Electroencephalogram revealed an abnormal sharp wave and seizure discharges resembling those of epilepsy. There was parenchymal inflammation, perivascular cuffs, neuronal degeneration, and glial reactions. Virus antigen was detected immunohistologically in the neurons and ependymal cells. Thus, CDV infection in squirrel monkeys provides an animal model for viral encephalitis and epilepsy.
用犬瘟热病毒（CDV）对松鼠猴进行脑内接种，引发了病毒性脑炎的急性神经症状。脑电图显示出异常的尖波和类似癫痫的发作性放电。存在实质炎症、血管周围套袖现象、神经元变性和神经胶质反应。通过免疫组织化学方法在神经元和室管膜细胞中检测到病毒抗原。因此，松鼠猴感染CDV为病毒性脑炎和癫痫提供了一种动物模型。
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