皮肤对丙二醇的反应。

Skin reactions to propylene glycol.

作者信息

Hannuksela M, Pirilä V, Salo O P

机构信息

Department of Dermatology, University Central Hospital, Helsinki, Finland.

出版信息

Contact Dermatitis. 1975;1(2):112-6. doi: 10.1111/j.1600-0536.1975.tb05336.x.

DOI:10.1111/j.1600-0536.1975.tb05336.x

PMID:233872

Abstract

Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. All the year round, the number of positive reactions to PG was 12.5% to EG 4.9%, and to PEG 400 0.3%. A total of 30% of the positive reactions to PG were allergic in appearance. Also the new fatty alcohol-PG bases of Metosyn ointment and Topilar ointment as well as Metosyn ointment (fluocinonide) itself provoked reactions in a great number of patients with positive reactions to PG, as is. The reactions to PG were considered to be truly allergic in four cases. In them, positive reactions were elicited by testing with high dilutions of PG and by applying the glycol in the patients' armpits as an open test. It is concluded that PG and topical preparations containing it in high concentrations should not be used with occlusion, and that allergic reactions must be watched.

摘要

采用斑贴试验法，对1556例湿疹患者原样测试了丙二醇（PG）、乙二醇（EG）和聚乙二醇400（PEG 400）。全年中，对PG呈阳性反应的比例为12.5%，对EG为4.9%，对PEG 400为0.3%。对PG呈阳性反应的患者中，共有30%的反应在外观上属于过敏反应。同样，美托松软膏和托皮拉软膏新的脂肪醇 - PG基质以及美托松软膏（氟轻松）原样也在大量对PG呈阳性反应的患者中引发了反应。有4例对PG的反应被认为是真正的过敏反应。在这些病例中通过用高稀释度的PG进行测试以及将二醇涂抹在患者腋窝进行开放性试验引发了阳性反应。得出的结论是，PG以及高浓度含PG的局部制剂不应封闭使用，并且必须留意过敏反应。