对聚乙二醇的速发型和迟发型过敏性接触反应。
Immediate and delayed allergic contact reactions to polyethylene glycol.
作者信息
Fisher A A
出版信息
Contact Dermatitis. 1978 Jun;4(3):135-8. doi: 10.1111/j.1600-0536.1978.tb03759.x.
The lower molecular weight liquid polyethylene glycols (PEG) varying from 200 to 700 are extensively used as solvent vehicles in topical medicaments. Four patients showed allergic reactions to these liquid polyethylene glycols in topical medications. Two had immediate urticarial reactions to PEG 400. Two other patients had delayed allergic eczematous reactions, one to PEG 200, and one to PEG 300. Cross reactions occurred between PEG 200, 300 and 400, but not between these liquid polyethylenes and the higher molecular weight solid polyethylenes from 1000 to 6000.
分子量在200至700之间的低分子量液态聚乙二醇（PEG）被广泛用作局部用药的溶剂载体。4例患者在局部用药时对这些液态聚乙二醇产生了过敏反应。2例对PEG 400出现即刻荨麻疹反应。另外2例患者出现迟发性过敏性湿疹反应，1例对PEG 200过敏，1例对PEG 300过敏。PEG 200、300和400之间发生了交叉反应，但这些液态聚乙烯与分子量在1000至6000之间的高分子量固态聚乙烯之间未发生交叉反应。
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