Rothwell J T, Harper P A, Hartley W J, Gumbrell R C, Meischke H R
New South Wales Agriculture and Fisheries, Regional Veterinary Laboratory, Camden, Australia.
J Wildl Dis. 1990 Apr;26(2):275-8. doi: 10.7589/0090-3558-26.2.275.
A probable neurovisceral lysosomal storage disease is reported, for the first time, in immature red and grey kangaroos (Macropus rufus and M. giganteus). Foamy, pale eosinophilic, periodic acid-Schiff positive, intracytoplasmic material was stored in the liver, lymphoid tissue, kidney, adrenal gland, stomach, blood vessels and central nervous system. Extensive Wallerian-type degeneration was present in the central nervous system. Electron microscopic study of one animal revealed electron dense, cytoplasmic lamellar bodies in neurons and foamy visceral cells. The disease differs from other reported storage diseases in the distribution and nature of the lesions.
首次报道了在未成熟的红袋鼠和灰袋鼠（赤大袋鼠和大灰袋鼠）中存在一种可能的神经内脏溶酶体贮积病。泡沫状、淡嗜酸性、过碘酸希夫染色阳性的胞质内物质贮积于肝脏、淋巴组织、肾脏、肾上腺、胃、血管和中枢神经系统。中枢神经系统存在广泛的华勒氏型变性。对一只动物的电子显微镜研究显示，神经元和内脏泡沫细胞中有电子致密的胞质层状体。该疾病在病变的分布和性质上与其他已报道的贮积病不同。
