MMP-9（-1562C:T）多态性作为重度子痫前期易感性的生物标志物。
MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia.
机构信息
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Biomark Med. 2013 Feb;7(1):93-8. doi: 10.2217/bmm.12.95.
AIM
To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia.
PATIENTS & METHODS: MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women.
RESULTS
A significantly higher frequency of MMP-9 CT genotype was observed in both mild and severe pre-eclamptic women compared with controls. In the presence of CT + TT genotype the risk of severe pre-eclampsia increased 2.37-fold (p = 0.02). In women with early-onset pre-eclampsia the frequency of MMP-9 CT + TT genotype was significantly higher (p = 0.045) compared with those with late-onset pre-eclampsia.
CONCLUSION
The MMP-9 variant could be a useful biomarker of susceptibility to severe pre-eclampsia and early-onset severe pre-eclampsia.
目的
探讨 MMP-9（-1562C>T）多态性作为子痫前期易感性生物标志物的作用。
患者与方法
检测了 160 例轻度和重度子痫前期及 112 例健康孕妇的 MMP-9 变异体。
结果
与对照组相比，轻度和重度子痫前期患者 MMP-9 CT 基因型的频率明显升高。存在 CT + TT 基因型时，重度子痫前期的风险增加 2.37 倍（p = 0.02）。与晚发型子痫前期相比，早发型子痫前期患者 MMP-9 CT + TT 基因型的频率明显更高（p = 0.045）。
结论
MMP-9 变异体可能是严重子痫前期和早发型严重子痫前期易感性的有用生物标志物。
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