Medical Physics, BC Cancer Agency, Vancouver Centre, Vancouver, British Columbia, Canada.
Med Phys. 2013 Feb;40(2):021707. doi: 10.1118/1.4773883.
To commission and benchmark a vendor-supplied (Varian Medical Systems) Monte Carlo phase-space data for the 6 MV flattening filter free (FFF) energy mode on a TrueBeam linear accelerator for the purpose of quality assurance of clinical volumetric modulated arc therapy (VMAT) treatment plans. A method for rendering the phase-space data compatible with BEAMnrc/DOSXYZnrc simulation software package is presented.
Monte Carlo (MC) simulations were performed to benchmark the TrueBeam 6 MV FFF phase space data that have been released by the Varian MC Research team. The simulations to benchmark the phase space data were done in three steps. First, the original phase space which was created on a cylindrical surface was converted into a format that was compatible with BEAMnrc. Second, BEAMnrc was used to create field size specific phase spaces located underneath the jaws. Third, doses were calculated with DOSXYZnrc in a water phantom for fields ranging from 1 × 1 to 40 × 40 cm(2). Calculated percent depth doses (PDD), transverse profiles, and output factors were compared with measurements for all the fields simulated. After completing the benchmarking study, three stereotactic body radiotherapy (SBRT) VMAT plans created with the Eclipse treatment planning system (TPS) were calculated with Monte Carlo. Ion chamber and film measurements were also performed on these plans. 3D gamma analysis was used to compare Monte Carlo calculation with TPS calculations and with film measurement.
For the benchmarking study, MC calculated and measured values agreed within 1% and 1.5% for PDDs and in-field transverse profiles, respectively, for field sizes >1 × 1 cm(2). Agreements in the 80%-20% penumbra widths were better than 2 mm for all the fields that were compared. With the exception of the 1 × 1 cm(2) field, the agreement between measured and calculated output factors was within 1%. It is of note that excellent agreement in output factors for all field sizes including highly asymmetric fields was achieved without accounting for backscatter into the beam monitor chamber. For the SBRT VMAT plans, the agreement between Monte Carlo and ion chamber point dose measurements was within 1%. Excellent agreement between Monte Carlo, treatment planning system and Gafchromic film dose distribution was observed with over 99% of the points in the high dose volume passing the 3%, 3 mm gamma test.
The authors have presented a method for making the Varian IAEA compliant 6 MV FFF phase space file of the TrueBeam linac compatible with BEAMnrc/DOSXYZnrc. After benchmarking the modified phase space against measurement, they have demonstrated its potential for use in MC based quality assurance of complex delivery techniques.
为了对瓦里安医疗系统公司提供的用于 TrueBeam 线性加速器 6 MV 无均整滤过自由(FFF)能量模式的束流空间数据进行认证和基准测试,以便对临床容积调强弧形治疗(VMAT)计划的质量保证进行验证。提出了一种将束流空间数据转换为 BEAMnrc/DOSXYZnrc 模拟软件包兼容格式的方法。
瓦里安 MC 研究团队发布了 TrueBeam 6 MV FFF 束流空间数据,我们对其进行了 MC 模拟来进行基准测试。为了对束流空间数据进行基准测试,我们分三步进行。首先,将在圆柱面上创建的原始束流空间转换为与 BEAMnrc 兼容的格式。其次,使用 BEAMnrc 生成位于限束器下方的适用于不同射野大小的束流空间。最后,使用 DOSXYZnrc 在水模体中对 1×1 至 40×40 cm2 的射野进行剂量计算。对所有模拟射野的百分深度剂量(PDD)、横向 profiles 和输出因子进行了计算,并与测量值进行了比较。在完成基准测试研究后,我们使用 Eclipse 治疗计划系统(TPS)对三个立体定向体部放射治疗(SBRT)VMAT 计划进行了 MC 计算。我们还对这些计划进行了电离室和胶片测量。使用 3D 伽马分析比较了 MC 计算与 TPS 计算和胶片测量的结果。
在基准测试研究中,MC 计算值和测量值在 PDD 和射野内横向 profiles 方面的一致性分别在 1%和 1.5%以内,对于大于 1×1 cm2 的射野。对于所有进行比较的射野,80%-20%半影宽度的一致性优于 2mm。除了 1×1 cm2 的射野之外,测量值和计算值之间的输出因子一致性在 1%以内。值得注意的是,在不考虑反向散射到束流监测腔的情况下,对于所有射野大小,包括高度不对称的射野,都可以实现非常好的输出因子一致性。对于 SBRT VMAT 计划,MC 与电离室点剂量测量之间的一致性在 1%以内。MC、TPS 和 Gafchromic 胶片剂量分布之间具有极好的一致性,超过 99%的高剂量体积的点通过了 3%、3mm 的伽马测试。
作者提出了一种方法,可将瓦里安 IAEA 合规的 6 MV FFF 束流空间文件与 TrueBeam 直线加速器的 BEAMnrc/DOSXYZnrc 兼容。在对修改后的束流空间进行测量基准测试后,他们证明了其在基于 MC 的复杂传输技术质量保证中的应用潜力。