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Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy.

作者信息

Klopstock T, Metz G, Yu-Wai-Man P, Büchner B, Gallenmüller C, Bailie M, Nwali N, Griffiths P G, von Livonius B, Reznicek L, Rouleau J, Coppard N, Meier T, Chinnery P F

出版信息

Brain. 2013 Feb;136(Pt 2):e230. doi: 10.1093/brain/aws279. Epub 2013 Feb 6.

DOI:10.1093/brain/aws279
PMID:23388409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3572931/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2050/3572931/78781f6366ff/aws279f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2050/3572931/78781f6366ff/aws279f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2050/3572931/78781f6366ff/aws279f1p.jpg

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Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case.Leber 遗传性视神经病变是否可治疗？前瞻性和回顾性试验中艾地苯醌的结果令人鼓舞，并有一个说明性病例。
J Neuroophthalmol. 2012 Mar;32(1):54-7. doi: 10.1097/WNO.0b013e318241da45.
2
Idebenone treatment in Leber's hereditary optic neuropathy.艾地苯醌治疗Leber遗传性视神经病变。
Brain. 2011 Sep;134(Pt 9):e188. doi: 10.1093/brain/awr180. Epub 2011 Aug 2.
3
A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy.
线粒体疾病的治疗：过去、现在与未来
J Inherit Metab Dis. 2025 Jul;48(4):e70065. doi: 10.1002/jimd.70065.
4
Isolated and Syndromic Genetic Optic Neuropathies: A Review of Genetic and Phenotypic Heterogeneity.孤立性和综合征性遗传性视神经病变：遗传与表型异质性综述
Int J Mol Sci. 2025 Apr 20;26(8):3892. doi: 10.3390/ijms26083892.
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Indian J Ophthalmol. 2025 May 1;73(5):656-664. doi: 10.4103/IJO.IJO_2898_23. Epub 2025 Apr 24.
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Cureus. 2025 Mar 11;17(3):e80439. doi: 10.7759/cureus.80439. eCollection 2025 Mar.
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Front Neurol. 2025 Feb 18;16:1538358. doi: 10.3389/fneur.2025.1538358. eCollection 2025.
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J Neurol Sci. 1998 Oct 8;160(2):183-8. doi: 10.1016/s0022-510x(98)00239-1.
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Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve.Leber遗传性视神经病变：呼吸链功能障碍与视神经变性
Vision Res. 1998 May;38(10):1495-504. doi: 10.1016/s0042-6989(97)00444-6.
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Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study.
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