Bach Flemming W, Jensen Troels S, Kastrup Jens, Stigsby Bent, Dejgård Anders
Department of Neurology, Gentofte Hospital, CopenhagenDenmark Department of Neurology, Rigshospitalet, CopenhagenDenmark Department of Clinical Physiology, Bispebjerg Hospital, CopenhagenDenmark Department of Clinical Neurophysiology, Gentofte Hospital, CopenhagenDenmark Department of Neurology, Hvidøre Hospital, CopenhagenDenmark.
Pain. 1990 Jan;40(1):29-34. doi: 10.1016/0304-3959(90)91047-M.
In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.
