Moncada G, Sepúlveda D, Elphick K, Contente M, Estay J, Bahamondes V, Fernandez E, Oliveira O B, Martin J
Oper Dent. 2013 Sep-Oct;38(5):467-76. doi: 10.2341/12-335-C. Epub 2013 Feb 7.
Examining three bleaching systems, this in vivo clinical trial evaluated the relationship among tooth sensitivity, light activation, and agent concentration, and it correlated dental sensitivity with tooth thickness.
Eighty-seven volunteer patients were included. Inclusion criteria were the presence of anterior teeth without restorations as well as the absence of a previous bleaching experience and absence of noncarious cervical lesions or dental pain. Exclusion criteria included pregnancy or breastfeeding, a maximum of TF3 hypoplasia, tetracycline-fluorosis stains, malpositioned teeth, orthodontic treatment, periodontal disease, and/or analgesic/anti-inflammatory intake. Patients were randomly assigned to three bleaching groups: Group A (n=25) was treated with 15% H2O2 and nitrogenous-titanium-dioxide and was light activated (Lase Peroxide Lite, DMC, SaoCarlos, Sao Paulo, Brazil); Group B (n=27) was treated with 35% H2O2 and was light activated (Lase Peroxide Sensy, DMC); and Group C (n=35) was treated with 35% H2O2 (White Gold Office, Dentsply, 38West Clark Ave., Milford, USA) without light activation. Tooth sensitivity (TS) was self-reported by the patients using the visual analog scale (VAS) at baseline (TS0), immediately after treatment (TSI), and at seven days after treatment (TS7). In 46 patients, tooth thickness was determined by computed tomography. TS0, TSI, and TS7 were compared between the A and B groups to determine the effect of concentration and between the B and C groups to determine the effect of light using analysis of covariance. The correlation between tooth thickness and TSI was determined by Spearman Rho test (SPSS 15).
Eighty-seven patients were evaluated at baseline, and 61 were evaluated at seven days. Separated by groups, tooth sensitivity, expressed as VAS value at the time points TS0, TSI, and TS7, respectively, were as follows: Group A: 13.76 ± 13.53, 24.40 ± 25.24, and 5.94 ± 5.5; Group B: 15.07 ± 18.14, 42.4 ± 31.78, and 8.68 ± 17.99; and Group C: 10.80 ± 14.83, 31.51 ± 29.34, and 7.24 ± 9.2. Group A showed significantly lower tooth sensitivity than group B at TSI (p=0.032). No differences were observed in the tooth sensitivities between groups B and C. No correlation was encountered between tooth thickness and tooth sensitivity immediately after treatment (Rho=-0.088, p=0.563). The median tooth thickness was 2.78 ± 0.21 mm.
Increases in the concentration of bleaching agents directly affect tooth sensitivity, and LED/laser activation and tooth thickness are not correlated with tooth sensitivity after dental bleaching.
本体内临床试验研究了三种漂白系统,评估了牙齿敏感度、光激活和试剂浓度之间的关系,并将牙齿敏感度与牙齿厚度相关联。
纳入八十七名志愿者患者。纳入标准为存在无修复体的前牙,且既往无漂白经历、无非龋性颈部病变或牙痛。排除标准包括怀孕或哺乳期、最大TF3发育不全、四环素氟斑牙、牙齿错位、正畸治疗、牙周病和/或服用止痛/抗炎药物。患者被随机分为三个漂白组:A组(n = 25)用15%过氧化氢和含氮二氧化钛治疗并进行光激活(Lase Peroxide Lite,DMC,巴西圣保罗州圣卡洛斯);B组(n = 27)用35%过氧化氢治疗并进行光激活(Lase Peroxide Sensy,DMC);C组(n = 35)用35%过氧化氢(美国米尔福德市登士柏公司的White Gold Office,西克拉克大道38号)治疗,不进行光激活。患者使用视觉模拟量表(VAS)在基线(TS0)、治疗后即刻(TSI)和治疗后七天(TS7)自我报告牙齿敏感度(TS)。在46名患者中,通过计算机断层扫描确定牙齿厚度。使用协方差分析比较A组和B组之间的TS0、TSI和TS7,以确定浓度的影响;比较B组和C组之间的TS0、TSI和TS7,以确定光的影响。通过Spearman Rho检验(SPSS 15)确定牙齿厚度与TSI之间的相关性。
八十七名患者在基线时接受评估,六十一名患者在七天时接受评估。按组分开,在TS0、TSI和TS7时间点分别表示为VAS值的牙齿敏感度如下:A组:13.76±13.53、24.40±25.24和5.94±5.5;B组:15.07±18.14、42.4±31.78和8.68±17.99;C组:10.80±14.83、31.51±29.34和7.24±9.2。A组在TSI时的牙齿敏感度显著低于B组(p = 0.032)。B组和C组之间的牙齿敏感度未观察到差异。治疗后即刻牙齿厚度与牙齿敏感度之间未发现相关性(Rho = -0.088,p = 0.563)。牙齿厚度中位数为2.78±0.21毫米。
漂白剂浓度的增加直接影响牙齿敏感度,并且LED/激光激活和牙齿厚度与牙齿漂白后的牙齿敏感度无关。