Takahashi R, Manku M S, Jenkins K, Horrobin D F
Efamol Research Institute, Kentville, Nova Scotia, Canada.
Prostaglandins Leukot Essent Fatty Acids. 1990 Jan;39(1):65-7. doi: 10.1016/0952-3278(90)90175-k.
Abnormalities of vasoactive eicosanoid synthesis with age are reported. We observed an age-associated reduction of vascular prostacyclin production and thrombin-stimulated thromboxane A2 production in blood. Amounts of production of these eicosanoids were inversely related to plasma cholesterol levels. However, there were no such relationships in rats supplemented with cholesterol. Dietary cholesterol supplementation induced a reduction of thromboxane A2/prostacyclin ratio regardless of age. These results suggest that age-associated changes of blood cholesterol levels are closely linked with vasoactive eicosanoid synthesis and that excessive consumption of cholesterol may induce a compensatory reaction by reducing the thromboxane A2/prostacyclin ratio.
据报道，血管活性类花生酸合成随年龄增长出现异常。我们观察到，血液中血管前列环素生成量与年龄相关减少，凝血酶刺激的血栓素A2生成量也减少。这些类花生酸的生成量与血浆胆固醇水平呈负相关。然而，在补充胆固醇的大鼠中不存在这种关系。无论年龄如何，膳食补充胆固醇均会导致血栓素A2/前列环素比值降低。这些结果表明，血液胆固醇水平与年龄相关的变化与血管活性类花生酸合成密切相关，过量摄入胆固醇可能通过降低血栓素A2/前列环素比值诱导一种代偿反应。
