Henriksson P, Stamberger M, Diczfalusy U
Department of Medicine, Huddinge Hospital, Karolinska Institutet, Sweden.
Prostaglandins Leukot Med. 1987 Sep;29(1):71-7. doi: 10.1016/0262-1746(87)90098-9.
It is of great importance to clarify the role of thromboxane and prostacyclin in the process of atherosclerosis. In order to study this we induced atherosclerosis in rabbits through cholesterol feeding (1% w/w) for three to 12 weeks. After sacrifice the aorta was quickly removed and incubated. The in vitro thromboxane production measured as immunoreactive thromboxane B2 increased by 86 per cent in atherosclerotic vessels compared to control vessels (p less than 0.0005). The in vitro production of prostacyclin measured as immunoreactive 6-keto-prostaglandin F1 alpha showed a tendency to higher values in the atherosclerotic vessels compared to the control vessels (31%, p less than 0.025). This suggests that an increased thromboxane production rather than a decreased prostacyclin production might be important for the progression of atherosclerosis.
阐明血栓素和前列环素在动脉粥样硬化过程中的作用非常重要。为了研究这一点，我们通过给兔子喂食胆固醇（1% w/w）三至十二周来诱发动脉粥样硬化。处死后，迅速取出主动脉并进行孵育。以免疫反应性血栓素B2衡量的体外血栓素生成在动脉粥样硬化血管中比对照血管增加了86%（p小于0.0005）。以免疫反应性6-酮-前列腺素F1α衡量的前列环素体外生成在动脉粥样硬化血管中与对照血管相比有升高的趋势（31%，p小于0.025）。这表明血栓素生成增加而非前列环素生成减少可能对动脉粥样硬化的进展很重要。
