Department of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Burlington, VT 05405, USA.
Exerc Sport Sci Rev. 2013 Apr;41(2):93-9. doi: 10.1097/JES.0b013e31828bbcd8.
Skeletal muscle contractile function declines with age and age-associated diseases. Although muscle atrophy undoubtedly contributes to this decrease, recent findings suggest that reduced myofilament protein content and function also may participate. Based on these data, we propose that age- and disease-related alterations in myofilament proteins represent one molecular mechanism contributing to the development of physical disability.
骨骼肌收缩功能随年龄增长和与年龄相关的疾病而下降。尽管肌肉萎缩无疑促成了这种下降,但最近的发现表明,肌丝蛋白含量和功能的降低也可能参与其中。基于这些数据,我们提出,肌丝蛋白的年龄和疾病相关改变代表了导致身体残疾的一个分子机制。