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脊髓损伤男性下肢骨折后的发病率。

Morbidity following lower extremity fractures in men with spinal cord injury.

机构信息

Veterans Affairs Medical Center, Memphis, TN 38163, USA.

出版信息

Osteoporos Int. 2013 Aug;24(8):2261-7. doi: 10.1007/s00198-013-2295-8. Epub 2013 Feb 8.

Abstract

UNLABELLED

The Veterans Affairs Spinal Cord Dysfunction Registry from 2002 to 2007 was reviewed to determine whether men with spinal cord injury (SCI) and lower extremity fractures had an increased risk of complications compared to those without fractures. We determined that fractures are associated with significant consequences, particularly during the first month postfracture.

INTRODUCTION

Despite increasing longevity, patients with SCI have a substantial number of illnesses and comorbid conditions. Lower extremity fractures are frequent events in these patients. However, whether these fractures are associated with any increased risk of complications in SCI is not certain. The purpose of this report was to determine the impact of lower extremity fractures on morbidities in men with SCI.

METHODS

A population-based, nested, case-control (1,027 cases and 1,027 propensity-matched controls) of men enrolled in the Veterans Affairs Spinal Cord Dysfunction Registry from fiscal years 2002 to 2007 was reviewed to determine whether lower extremity fractures were associated with an increased risk for complications.

RESULTS

In propensity score models matched for demographic (age, race) and SCI-related injury factors (level/completeness of SCI), Veterans Affairs-service connection status, and comorbidities, at 1 month following the fracture, there was an increased risk for respiratory infections, pressure ulcers, urinary tract infections, thromboembolic events, depression, and delirium (p ≤ 0.03 for all). Over 12 months, the only complication more common in fracture cases was pressure ulcers (p < 0.01), with an absolute difference of less than 2 % when compared to controls. There was no significant increased risk of cardiac arrhythmias at any time examined following fracture (≥0.12).

CONCLUSIONS

Lower extremity fractures are associated with significant consequences in men with SCI during the first month postfracture, but they do not persist for a long term, except for pressure ulcers. Targeted interventions to prevent complications should be considered following lower extremity fractures in SCI, particularly in the first month following fracture.

摘要

背景

尽管患者的寿命有所延长,但患有脊髓损伤 (SCI) 的患者仍患有大量疾病和合并症。下肢骨折是这些患者中常见的事件。然而,这些骨折是否与 SCI 患者的并发症风险增加有关尚不确定。本报告的目的是确定下肢骨折对 SCI 男性患者发病率的影响。

方法

对 2002 年至 2007 年财政年度参加退伍军人事务部脊髓功能障碍登记处的男性患者进行了基于人群的嵌套病例对照研究(1027 例病例和 1027 例倾向评分匹配对照),以确定下肢骨折是否与并发症风险增加相关。

结果

在对年龄、种族和 SCI 相关损伤因素(SCI 水平/完整性)、退伍军人事务部服务关系状况和合并症进行倾向评分匹配的模型中,骨折后 1 个月,呼吸道感染、压疮、尿路感染、血栓栓塞事件、抑郁和谵妄的风险增加(所有 p 值均≤0.03)。在 12 个月内,骨折病例中唯一更常见的并发症是压疮(p<0.01),与对照组相比,差异绝对值小于 2%。骨折后任何时间检查均未发现心律失常风险显著增加(≥0.12)。

结论

下肢骨折与骨折后第一个月 SCI 男性患者的严重后果相关,但除压疮外,不会长期存在。在 SCI 患者发生下肢骨折后,应考虑采取针对性的干预措施来预防并发症,尤其是在骨折后第一个月。

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