Division of Specialty Care, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Center of Innovation for Complex Chronic Healthcare, Edward J. Hines, Jr. VA Hospital, Hines, Illinois, USA.
J Spinal Cord Med. 2024 Mar;47(2):293-299. doi: 10.1080/10790268.2023.2188391. Epub 2023 Mar 28.
Nearly 50% of all persons with a spinal cord injury/disorder (SCI/D) will sustain an osteoporotic fracture sometime in their life, with lower extremity fractures being the most common. There are a number of complications that can occur post fracture, including fracture malunion. To date, there have been no dedicated investigations of malunions among persons with SCI/D.
The primary objective of this study was to identify risk factors associated with fracture malunion among fracture-related (type of fracture, fracture location, initial fracture treatment) and SCI/D-related factors. Secondary objectives were to describe treatment of fracture malunions and complications following these malunions.
Veterans with SCI/D with an incident lower extremity fracture and subsequent malunion from Fiscal Year (FY) 2005-2015 were selected from the Veteran Health Administration (VHA) databases using International Classification of Diseases, 9th edition (ICD-9) codes for lower extremity fractures and malunion. These fracture malunion cases underwent electronic health record (EHR) review to abstract information on potential risk factors, treatments and complications for malunion. Twenty-nine cases were identified with a fracture malunion with 28 of them successfully matched with Veterans with a lower extremity fracture during FY2005-FY2014 without a malunion (matched 1:4) based on having an outpatient utilization date of care within 30 days of the fracture case. There was trend towards more nonsurgical treatment in the malunion group ( = 27, 96.43%) compared to the control group ( = 101, 90.18%) (P = 0.05), though fracture treatment proved not to be not associated with developing a malunion in univariate logistic regression analyses (OR = 0.30; 95% CI: 0.08-1.09). In multivariate analyses, Veterans with tetraplegia were significantly less likely (approximately 3-fold) to have a fracture malunion (OR = 0.38; 95% CI: 0.14-0.93) compared to those with paraplegia. Fracture malunion was significantly less likely to occur for fractures of the ankle (OR = 0.02; 95% CI: 0-0.13) or the hip (OR = 0.15; 95% CI: 0.03-0.56) compared to femur fractures. Fracture malunions were rarely treated. The most common complications following malunions were pressure injuries (56.3%) followed by osteomyelitis (25.0%).
Persons with tetraplegia as well as fractures of the ankle and hip (compared to the femur) were less likely to develop a fracture malunion. Attention to prevention of avoidable pressure injuries following a fracture malunion is important.
将近 50%的脊髓损伤/疾病(SCI/D)患者在其一生中会发生骨质疏松性骨折,下肢骨折最为常见。骨折后会发生许多并发症,包括骨折愈合不良。迄今为止,尚无专门针对 SCI/D 患者骨折愈合不良的研究。
本研究的主要目的是确定与骨折相关的(骨折类型、骨折部位、初始骨折治疗)和 SCI/D 相关因素相关的骨折愈合不良的危险因素。次要目的是描述骨折愈合不良的治疗方法以及这些愈合不良后的并发症。
使用国际疾病分类第 9 版(ICD-9)代码从退伍军人健康管理局(VHA)数据库中选择 FY2005-FY2015 年间发生下肢骨折和随后骨折愈合不良的 SCI/D 退伍军人。这些骨折愈合不良病例接受电子病历(EHR)审查,以提取与愈合不良相关的潜在危险因素、治疗方法和并发症的信息。共确定了 29 例骨折愈合不良病例,其中 28 例与 FY2005-FY2014 年间下肢骨折但无愈合不良的退伍军人(28 例)成功匹配(28 例:1:4),其门诊就诊日期在骨折病例后 30 天内。与对照组(28 例:101 例,90.18%)相比,愈合不良组(27 例:96.43%)更倾向于非手术治疗(P=0.05),尽管多变量逻辑回归分析表明骨折治疗与愈合不良无关(OR=0.30;95%CI:0.08-1.09)。在多变量分析中,与截瘫患者相比,四肢瘫痪患者发生骨折愈合不良的可能性显著降低(约 3 倍)(OR=0.38;95%CI:0.14-0.93)。与股骨骨折相比,踝关节(OR=0.02;95%CI:0-0.13)或髋关节(OR=0.15;95%CI:0.03-0.56)骨折愈合不良的可能性显著降低。骨折愈合不良很少得到治疗。愈合不良后最常见的并发症是压疮(56.3%),其次是骨髓炎(25.0%)。
四肢瘫痪以及踝关节和髋关节(与股骨相比)骨折的患者发生骨折愈合不良的可能性较低。注意预防骨折愈合不良后的可避免性压疮非常重要。