微小 RNA181a 影响急性白血病中 HMGB1 和 CD4 的表达。

MicroRNA 181a influences the expression of HMGB1 and CD4 in acute Leukemias.

机构信息

University of Rostock, Division of Medicine, Department of Hematology/Oncology/Palliative Medicine, Ernst-Heydemann-Str. 6, 18057 Rostock, Germany.

出版信息

Anticancer Res. 2013 Feb;33(2):445-52.

PMID:23393335

Abstract

Dysregulation of microRNAs (miRs) has been linked to several types of cancer. In the present study, we investigated the expression of miR-181a in different leukemia cell lines and healthy hematopoietic cells, as well as its influence on cell proliferation, metabolic activity and potential targets. Expression of miR-181a differed between various leukemia cell lines and mature blood cells. Inhibition of miR 181a expression in T- and B-Acute Lymphoblastic Leukemia (ALL) cells revealed an influence on the potential targets High-Mobility-Group-Protein B1 (HMGB1) and Cluster of Differentiation 4 (CD4). Overexpression of miR-181a in AML cells led to a significant decrease in cell proliferation and metabolic activity. The present data indicate a possible role of this specific miRNA in immunogenicity.

摘要

miRNAs（miRs）的失调与几种类型的癌症有关。在本研究中，我们研究了 miR-181a 在不同白血病细胞系和健康造血细胞中的表达，以及其对细胞增殖、代谢活性和潜在靶标的影响。miR-181a 的表达在不同的白血病细胞系和成熟血细胞之间存在差异。抑制 T-和 B-急性淋巴细胞白血病（ALL）细胞中 miR 181a 的表达，揭示了对潜在靶标高迁移率族蛋白 B1（HMGB1）和分化簇 4（CD4）的影响。在 AML 细胞中过表达 miR-181a 导致细胞增殖和代谢活性显著下降。本数据表明这种特定 miRNA 在免疫原性方面可能具有一定的作用。