Chakraborty Joydeep, Nagri Shivashankara Kaniyoor, Gupta Amit Narayan, Bansal Ankush
Assistant Professor, Department of Medicine, Kasturba Medical College, Manipal-576104, India.
Australas Med J. 2011;4(8):439-41. doi: 10.4066/AMJ.2011.777. Epub 2011 Aug 31.
Amitraz, a centrally acting alpha-2 adrenergic agonist, is increasingly being used for treatment of ectoparasitic infestation in cattle. Its effects in humans may mimic organophosphate poisoning. We report a case of poisoning after suicidal ingestion of Amitraz. The patient presented in a deeply comatose state with respiratory depression, bradycardia and mydriasis (instead of miosis, the more common presentation in previous reports). He recovered completely within 24 hours with adequate supportive measures. The importance of this case report is highlighted by the increasing use of this compound, the life-threatening presentation, the excellent prognosis with early recognition and supportive management and the limited human toxicological data.
双甲脒是一种中枢作用的α-2肾上腺素能激动剂，越来越多地用于治疗牛的体外寄生虫感染。它对人类的影响可能类似于有机磷中毒。我们报告一例因自杀性摄入双甲脒而中毒的病例。患者呈深度昏迷状态，伴有呼吸抑制、心动过缓和瞳孔散大（与之前报告中更常见的瞳孔缩小相反）。通过适当的支持措施，他在24小时内完全康复。随着这种化合物使用的增加、危及生命的表现、早期识别和支持性管理带来的良好预后以及有限的人体毒理学数据，本病例报告的重要性得到了凸显。
