Jones R D
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Vet Hum Toxicol. 1990 Oct;32(5):446-8.
There are no reports of xylene/amitraz ingestion in children. Studies have characterized the adverse reactions caused by dermal applications in dogs, but the mechanisms involved were undetermined Accidental ingestion of the product by a child prompted a retrospective search of the medical records of the Georgia Animal Poison Information Center to profile the signalment, clinical signs, route of exposure and target sites of the suspected toxicosis in dogs. Clinical signs of depression, ataxia, stupor, and coma were most attributable to the xylene and propylene oxide components. Hyperglycemia, hypotension, and bradycardia were probably attributable to the alpha-2 adrenoceptor agonist action of amitraz. Most reports were initiated by owners, using the prescription product at home.
没有儿童摄入二甲苯/双甲脒的报告。已有研究描述了狗经皮肤接触该产品所引起的不良反应，但相关机制尚未明确。一名儿童意外摄入该产品后，促使研究人员对佐治亚动物中毒信息中心的医疗记录进行回顾性检索，以分析狗疑似中毒的特征、临床症状、接触途径和靶器官。抑郁、共济失调、木僵和昏迷等临床症状主要归因于二甲苯和环氧丙烷成分。高血糖、低血压和心动过缓可能归因于双甲脒的α-2肾上腺素能受体激动作用。大多数报告由主人发起，他们在家中使用该处方药。
