Bose Sonali, Jun Jonathan, Diette Gregory B
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
J Asthma. 2013 Mar;50(2):219-21. doi: 10.3109/02770903.2012.757773.
High-frequency chest wall oscillation (HFCWO) has been traditionally implemented for airway secretion clearance in conditions such as cystic fibrosis (CF) and bronchiectasis. There have been few reports of its use in refractory asthma.
A 36-year-old, non-smoker male presented with a lifelong history of poorly controlled asthma. Despite multiple controller medications, he reported daily chest congestion, copious phlegm, and frequent exacerbations. Imaging, blood work, and bronchoscopy ruled out atypical infections, immunodeficiency, CF, and other chronic conditions. Pulmonary function tests supported a diagnosis of asthma.
We initiated HFCWO therapy twice daily in addition to standard inhaled pharmacological therapy. After 2 months, the patient noted resolution of respiratory symptoms as well as improvement in lung function. He remained symptom-free at his 2-year follow-up.
High-frequency chest oscillation may be useful in phenotypes of asthma characterized by prominent mucus hypersecretion.
高频胸壁振荡（HFCWO）传统上用于囊性纤维化（CF）和支气管扩张等病症的气道分泌物清除。关于其在难治性哮喘中的应用报道很少。
一名36岁、不吸烟男性，有哮喘控制不佳的终生病史。尽管使用了多种控制药物，但他仍报告每天胸部有闷堵感、大量痰液且频繁发作。影像学检查、血液检查和支气管镜检查排除了非典型感染、免疫缺陷、CF和其他慢性疾病。肺功能测试支持哮喘诊断。
除标准吸入药物治疗外，我们开始每天两次进行HFCWO治疗。2个月后，患者指出呼吸道症状消失，肺功能改善。在2年随访中他一直无症状。
高频胸壁振荡可能对以显著黏液分泌过多为特征的哮喘表型有用。
