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支架辅助栓塞治疗 100 例大脑中动脉动脉瘤。

Stent-assisted embolization of 100 middle cerebral artery aneurysms.

机构信息

Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois 60612, USA.

出版信息

J Neurosurg. 2013 May;118(5):950-5. doi: 10.3171/2013.1.JNS121298. Epub 2013 Feb 8.

DOI:10.3171/2013.1.JNS121298
PMID:23394339
Abstract

OBJECT

The introduction of intracranial stents to aneurysm treatment allows endovascular repair of nearly all aneurysms, but the safety and durability of stent-assisted embolization of middle cerebral artery (MCA) aneurysms is unclear.

METHODS

Ninety-one patients with 100 complex MCA aneurysms not amenable to simple coiling were treated with stent-assisted embolization as a first option. Technical and clinical results, initial follow-up imaging, and long-term annual MR angiography (MRA) were reviewed.

RESULTS

Intracranial stents were successfully deployed in all 100 aneurysms. There was 1 case of significant neurological morbidity (1%) and 1 case of death (1%) related to treatment. Initial posttreatment angiography revealed complete occlusion of 48 aneurysms (48%), a residual neck in 21 (21%), and residual aneurysm filling in 31 (31%). Follow-up imaging performed in 85 (90.4%) of a possible 94 aneurysms showed complete occlusion of 77 aneurysms (90.6%), residual neck in 3 (3.5%), and residual filling in 5 (5.9%). Four aneurysms (4.7%) required retreatment. Long-term MRA follow-up revealed stability or progressive thrombosis in 47 (97.9%) of 48 aneurysms. In 11 patients Y-configuration stenting caused only 1 minor complication and provided durable occlusion in all cases.

CONCLUSIONS

Stent-assisted techniques increase the number of aneurysms that may be treated endovascularly and represent an acceptable alternative to craniotomy. Stents provided adequate vessel reconstruction, low complication rates, and good long-term occlusion.

摘要

目的

颅内支架的引入使得几乎所有动脉瘤都可以通过血管内修复来治疗,但支架辅助栓塞治疗大脑中动脉(MCA)动脉瘤的安全性和耐久性尚不清楚。

方法

91 例 100 个复杂 MCA 动脉瘤患者,因无法单纯进行线圈栓塞而选择支架辅助栓塞作为首选治疗方法。回顾分析了技术和临床结果、初始随访影像学检查和长期每年磁共振血管造影(MRA)。

结果

100 个动脉瘤中均成功植入颅内支架。有 1 例(1%)出现严重神经功能障碍和 1 例(1%)与治疗相关的死亡。初始治疗后血管造影显示 48 个动脉瘤(48%)完全闭塞,21 个动脉瘤(21%)有残余瘤颈,31 个动脉瘤(31%)有残余瘤腔显影。在 94 个可能的动脉瘤中,对 85 个(90.4%)进行了随访影像学检查,结果显示 77 个动脉瘤(90.6%)完全闭塞,3 个动脉瘤(3.5%)有残余瘤颈,5 个动脉瘤(5.9%)有残余瘤腔显影。4 个动脉瘤(4.7%)需要再次治疗。长期 MRA 随访显示,48 个动脉瘤中有 47 个(97.9%)稳定或进行性血栓形成。在 11 例 Y 型支架患者中仅出现 1 例轻微并发症,所有病例均获得持久闭塞。

结论

支架辅助技术增加了可通过血管内治疗的动脉瘤数量,是开颅手术的一种可接受的替代方法。支架提供了足够的血管重建,并发症发生率低,长期闭塞效果好。

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