Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
J Affect Disord. 2013 Aug 15;150(1):156-9. doi: 10.1016/j.jad.2013.01.010. Epub 2013 Feb 8.
Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults.
Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system.
The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women.
A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument.
The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology.
遗传因素在创伤后应激障碍（PTSD）的发展中起着重要作用，而创伤后应激障碍是在暴露于创伤性事件之后发生的。然而，这种疾病的分子遗传基础在很大程度上仍未得到解决。本研究调查了在高度创伤的中国成年人样本中，ADCYAP1R1 rs2267735 基因型与 PTSD 症状之间的关联。
参与者包括 326 名在 2008 年汶川地震中经历过创伤并在灾难中失去孩子的受害者。使用 PTSD 检查表（PCL）评估 PTSD 症状。使用 Sequenom iPlex 化学和 MassARRAY 系统对 ADCYAP1R1 rs2267735 SNP 进行基因分型。
结果表明，尽管 rs2267735'CC'基因型与总 PTSD 症状无关，但它可以显著预测女性 PTSD 的情感麻木症状的严重程度。
使用的是暴露于特定创伤性事件的相对较小的样本，并且 PTSD 是使用自我报告的工具进行评估的。
这些发现表明，PACAP-PAC1 受体途径可能在女性对创伤性应激的反应中起着重要作用，并对更好地理解和治疗创伤后精神病理学具有重要意义。
Zotero 插件