Cao Chengqi, Wang Li, Wang Richu, Qing Yulan, Zhang Jianxin
aKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences bUniversity of Chinese Academy of Sciences, Beijing, China.
Psychiatr Genet. 2014 Dec;24(6):257-61. doi: 10.1097/YPG.0000000000000048.
Genetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms.
遗传因素在经历创伤性事件后创伤后应激障碍（PTSD）的发展中起着重要作用。然而，这种疾病的分子遗传学基础尚未明确。本研究调查了位于转录控制区的单核苷酸多态性（SNP）——色氨酸羟化酶2（TPH2）rs11178997基因型与PTSD症状之间的关联。共有326名在2008年致命的汶川地震中受灾且在灾难中失去孩子的中国成年人参与了本研究。使用PTSD检查表测量PTSD症状，并通过MassARRAY系统成功对该SNP进行基因分型。结果表明，虽然rs11178997基因型与PTSD总症状无关，但它可以显著预测女性PTSD回避症状的严重程度。这些发现支持TPH2可能在PTSD的发展中发挥重要的功能作用，并为关于PTSD症状的遗传基础和性别特异性表达的有限文献做出了贡献。
