Cao Chengqi, Wang Li, Cao Xing, Dong Chongya, Liu Ping, Luo Shu, Cui Hong, Yang Jun, Zhang Jianxin
Laboratory for Traumatic Stress studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
Laboratory for Traumatic Stress studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
Asian J Psychiatr. 2017 Feb;25:138-141. doi: 10.1016/j.ajp.2016.10.028. Epub 2016 Nov 3.
This study examined the association between interaction of retinoid-related orphan receptor alpha (RORA) (rs8042149) genotype x trauma exposure and post-traumatic stress disorder (PTSD) symptoms.
A total of 1196 Chinese adults who suffered from a deadly 2008 Wenchuan earthquake participated in this study. PTSD symptoms were measured with the PTSD Checklist for DSM-5 (PCL-5). A custom-by-design 2×48-Plex SNPscan™Kit were used to genotype the RORA rs8042149 SNP.
Our results showed that the interaction of rs8042149 genotype x trauma exposure was associated with total PTSD symptoms in males. Moreover, the rs8042149 genotype x trauma exposure interaction was only associated with severity of the negative affect, anhedonia and dysphoric arousal symptoms in males.
A moderate sample exposed to a specific event was assessed with a self-reported PTSD measure.
This study provides preliminary evidence supporting the functional role of RORA in PTSD, and adds to the knowledge for understanding the genetic underpinnings of PTSD. Moreover, this study carries implications for understanding the comorbidity of PTSD and the sex-specific expression of PTSD's symptoms.
本研究探讨了维甲酸相关孤儿受体α（RORA）（rs8042149）基因型与创伤暴露的相互作用与创伤后应激障碍（PTSD）症状之间的关联。
共有1196名经历过2008年致命汶川地震的中国成年人参与了本研究。使用《精神疾病诊断与统计手册》第5版创伤后应激障碍检查表（PCL-5）测量PTSD症状。采用定制的2×48重SNPscan™试剂盒对RORA rs8042149单核苷酸多态性进行基因分型。
我们的结果表明，rs8042149基因型与创伤暴露的相互作用与男性PTSD总症状相关。此外，rs8042149基因型与创伤暴露的相互作用仅与男性负面影响、快感缺失和烦躁性觉醒症状的严重程度相关。
使用自我报告的PTSD测量方法对暴露于特定事件的适度样本进行了评估。
本研究提供了初步证据，支持RORA在PTSD中的功能作用，并增加了对PTSD遗传基础的理解。此外，本研究对理解PTSD的共病情况和PTSD症状的性别特异性表达具有启示意义。
