Vanparijs O, Hermans L, Marsboom R
Department of Parasitology, Janssen Pharmaceutica, Beerse, Belgium.
Vet Rec. 1990 Apr 7;126(14):332-3.
Diclazuril, a new anticoccidial drug, was tested in young pheasants artificially infected with the three most common pathogenic species of Eimeria, E colchici, E duodenalis and E phasiani. In two replicate experiments each with 40 birds the mortalities in the infected controls were 50 and 25 per cent. Diclazuril was administered in the feed at dose levels of 1, 2 and 4 ppm from the day before the inoculation of coccidia until the end of the test on day 6 after infection. The 1 ppm dose failed to inhibit the development of the parasite completely, as was shown by a reduction of the weight gain of the birds and the output of a small number of oocysts. Diclazuril at 2 or 4 ppm adequately controlled the infection, with weight gains similar to those of the uninfected controls. At all dose levels, mortality, intestinal lesions and diarrhoea were prevented.
地克珠利是一种新型抗球虫药，在人工感染三种最常见致病性艾美耳球虫（即雉鸡艾美耳球虫、十二指肠艾美耳球虫和鸡艾美耳球虫）的幼雉鸡中进行了试验。在两个重复实验中，每个实验有40只鸟，感染对照组的死亡率分别为50%和25%。从接种球虫前一天直到感染后第6天试验结束，地克珠利以1、2和4 ppm的剂量水平添加到饲料中给药。1 ppm的剂量未能完全抑制寄生虫的发育，这表现为鸟类体重增加减少以及有少量卵囊排出。2或4 ppm的地克珠利能充分控制感染，体重增加情况与未感染对照组相似。在所有剂量水平下，均能预防死亡、肠道病变和腹泻。
