Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil.
Am J Hypertens. 2014 Apr;27(4):508-13. doi: 10.1093/ajh/hps034. Epub 2013 Feb 7.
Blood pressure (BP) should be kept within a narrow range to allow adequate tissue perfusion. In particular, heart-rate variability (HRV) can be used to assess autonomic cardiovascular modulation, and flow-mediated dilation (FMD) can provide valuable information about the ability of the cardiovascular system to adapt to different pressures. Our objective in the study described here was to investigate the effect of a difference of 10mm Hg in mean arterial pressure (MAP) on endothelial function and autonomic balance in young and normotensive soccer players.
Twenty-nine young male soccer players (mean age 17.7 years) were divided into two groups according to their MAP (mm Hg): MAP-84 and MAP-94. The BP, FMD, HRV and maximum oxygen uptake (VO2max) of each group were measured.
Systolic BP (SBP) and diastolic BP (DBP) were significantly higher (P < 0.0001 and P < 0.006, respectively) in the MAP-94 group. There were no differences in VO2max and endothelial function in the two groups (P < 0.7699). However, the standard deviation (SD) of normal RR intervals (SDNN) and the square root of the mean squared differences in successive RR intervals (RMSSD) were significantly lower in the MAP-94 than in the MAP-84 group (P < 0.0001 and P < 0.005, respectively). In the MAP-94 group, both the high-and low-frequency components were significantly (P < 0.001, P < 0.021, P < 0.017, respectively) lower in both absolute and normalized units, whereas the LF/HF ratio was significantly (P < 0.012) higher.
Collectively, our findings indicate that in young soccer players, autonomic cardiovascular modulation is impaired when MAP is increased by 10mm Hg, even within an optimal range of BP and regardless of endothelial function and VO2max.
血压（BP）应保持在狭窄范围内，以允许足够的组织灌注。特别是，心率变异性（HRV）可用于评估自主心血管调节，而血流介导的扩张（FMD）可以提供有关心血管系统适应不同压力的能力的有价值的信息。我们在本研究中的目的是研究平均动脉压（MAP）相差 10mmHg 对年轻和正常血压足球运动员的内皮功能和自主平衡的影响。
根据 MAP（mmHg）将 29 名年轻男性足球运动员分为两组：MAP-84 和 MAP-94。测量每组的血压、FMD、HRV 和最大摄氧量（VO2max）。
MAP-94 组的收缩压（SBP）和舒张压（DBP）均显著升高（P<0.0001 和 P<0.006）。两组 VO2max 和内皮功能无差异（P<0.7699）。然而，正常 RR 间隔的标准差（SDNN）和相邻 RR 间隔均方差的平方根（RMSSD）在 MAP-94 组明显低于 MAP-84 组（P<0.0001 和 P<0.005）。在 MAP-94 组中，无论是绝对还是标准化单位，高频和低频成分均显著降低（P<0.001、P<0.021、P<0.017，分别），而 LF/HF 比值显著升高（P<0.012）。
总的来说，我们的研究结果表明，在年轻的足球运动员中，当 MAP 升高 10mmHg 时，即使在血压的最佳范围内，自主心血管调节也会受损，无论内皮功能和 VO2max 如何。
