Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil.
Arq Bras Cardiol. 2020 Jul;115(1):52-58. doi: 10.36660/abc.20180441. Epub 2020 Aug 7.
Background The family history of hypertension (FHH) imposes consistent risk for diverse chronic diseases that are accompanied by hypertension. Furthermore, the heart rate variability (HRV) and flow-mediated dilation (FMD) are both related to maximal oxygen uptake (VO2max), and are usually impaired during hypertension Objective To compare the autonomic modulation, the endothelial function (EF) and maximum oxygen uptake (VO2max) of young athletes, separated according to their parents' blood pressure (BP) history, in order to study the influence of their genetic background on those parameters. Methods A total of 46 young male soccer players (18±2 years of age) were divided into four groups: 1-normotensive father and mother (FM-N); 2-only father was hypertensive (F-H); 3-only mother was hypertensive (M-H); 4-father and mother were hypertensive (FM-H). Measurements of BP, FMD, HRV and VO2maxwere performed. The significance level adopted in the statistical analysis was 5%. Results The standard deviation of normal RR intervals (SDNN; FM-N=314±185; FM-H=182.4± 57.8), the square root of the mean squared differences in successive RR intervals (RMSSD; FM-N=248±134; FM-H=87±51), the number of interval differences of successive NN intervals greater than 50ms (NN50; FM-N=367±83.4; FM-H=229±55), the ratio derived by dividing NN50 by the total number of NN intervals (pNN50; FM-N=32.4±6.2; FM-H=21.1±5.3) and the high (HF; FM-N=49±8.9; FM-H=35.3±12) and low-frequency (LF; FM-N=50.9±8.9; FM-H=64.6±12) components, in normalized units (%), were significantly lower in the FM-H group than in the FM-N group (p<0.05). On the other hand, the LF/HF ratio (ms2) was significantly higher (p<0.05). We found no significant difference between the groups in VO2maxand FMD (p<0.05). Conclusions In young male soccer players, the FHH plays a potentially role in autonomic balance impairment, especially when both parents are hypertensive, but present no changes in VO2maxand FMD. In this case, there is a decrease in the sympathetic-vagal control, which seems to precede the endothelial damage (Arq Bras Cardiol. 2020; 115(1):52-58).
高血压家族史（FHH）会使各种伴有高血压的慢性疾病的风险持续存在。此外，心率变异性（HRV）和血流介导的舒张功能（FMD）均与最大摄氧量（VO2max）相关，并且在高血压期间通常会受到损害。目的：比较根据父母血压（BP）史分组的年轻运动员的自主调节、内皮功能（EF）和最大摄氧量（VO2max），以研究遗传背景对这些参数的影响。方法：共纳入 46 名年轻男性足球运动员（18±2 岁），分为 4 组：1-父母血压正常（FM-N）；2-父亲高血压（F-H）；3-母亲高血压（M-H）；4-父母均高血压（FM-H）。测量血压、FMD、HRV 和 VO2max。统计分析的显著性水平为 5%。结果：正常 RR 间期标准差（SDNN；FM-N=314±185；FM-H=182.4±57.8）、连续 RR 间期均方根差值（RMSSD；FM-N=248±134；FM-H=87±51）、连续 NN 间期差值大于 50ms 的 NN 间期数（NN50；FM-N=367±83.4；FM-H=229±55）、NN50 与总 NN 间期比值（pNN50；FM-N=32.4±6.2；FM-H=21.1±5.3）以及高频（HF；FM-N=49±8.9；FM-H=35.3±12）和低频（LF；FM-N=50.9±8.9；FM-H=64.6±12）在标准化单位（%）中，FM-H 组显著低于 FM-N 组（p<0.05）。另一方面，LF/HF 比值（ms2）显著升高（p<0.05）。两组间 VO2max和 FMD 无显著差异（p<0.05）。结论：在年轻男性足球运动员中，FHH 可能在自主平衡受损中发挥作用，尤其是当父母双方均患有高血压时，但 VO2max和 FMD 无变化。在这种情况下，交感神经-迷走神经控制减弱，似乎先于内皮损伤（Arq Bras Cardiol. 2020; 115(1):52-58）。
