Briançon D, D'Aranda P, Quillet P, Duplan B, Chapuy M C, Arlot M, Meunier P J
Hôpital de Rheumatologie Reine Hortense, Aix-les-Bains, France.
J Bone Miner Res. 1990 Mar;5 Suppl 1:S71-3. doi: 10.1002/jbmr.5650051310.
To assess whether an interval of a few hours would be advisable between an intake of sodium fluoride (NaF) and that of calcium salts when treating osteoporotic patients with vertebral collapse, we carried out three pharmacokinetic studies in 12 healthy fasting volunteer subjects to compare the fluoride bioavailability provided by NaF alone and NaF combined with two calcium salts. The results were as follows: (1) When NaF is accompanied by calcium, the fluoride peak level is lower and delayed. (2) Fluoride absorption varied greatly among individuals in both experiments, but none of the 6 subjects proved to be nonabsorbers. (3) The areas under the curves obtained with each of the three preparations were not significantly different, but 24-h urinary fluoride was significantly lower in volunteers receiving simultaneously NaF and calcium salts than in volunteers receiving only NaF.
为了评估在治疗伴有椎体骨折的骨质疏松症患者时，摄入氟化钠（NaF）和钙盐之间间隔数小时是否可取，我们对12名健康的空腹志愿者进行了三项药代动力学研究，以比较单独使用NaF以及NaF与两种钙盐联合使用时的氟生物利用度。结果如下：（1）当NaF与钙同时存在时，氟的峰值水平较低且出现延迟。（2）在两个实验中，个体之间的氟吸收差异很大，但6名受试者中没有一人被证明是无吸收者。（3）三种制剂各自获得的曲线下面积没有显著差异，但同时接受NaF和钙盐的志愿者24小时尿氟明显低于仅接受NaF的志愿者。
